methyl (E)-3-cyano-2-methylprop-2-enoate | 203586-93-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: methyl (E)-3-cyano-2-methylprop-2-enoate
• CAS: 203586-93-0
• 化学式: C₆H₇NO₂
• 分子量: 125.127
• InChiKey: DPLVRKFSSCKURP-HWKANZROSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  50.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  methyl (E)-3-cyano-2-methylprop-2-enoate 在 葡萄糖 、 GDH 、 OYE 3 enzyme 、 nicotinamide adenine dinucleotide phosphate 作用下， 以 二甲基亚砜 为溶剂， 反应 24.0h， 以97%的产率得到
  参考文献：
  名称：

  旧的黄色酶介导的还原β-氰基-α，β-不饱和酯的合成，用于手性结构单元的合成：反应的立体化学分析†

  摘要：

  为了扩大这种反应在制备有机化学领域中的适用性，研究了贝克酵母和老黄酶介导的β-氰基-α，β-不饱和酯的碳-碳双键还原。对映选择性还原这些双官能化基板的合成显着性示出通过考虑饱和手性氰基酯转化为γ 2-用于折叠剂化学应用的氨基酸衍生物。通过氘标记实验仔细分析了生物转化的立体化学结果。该分析的结果被用来合理化底物控制对某类烯-还原酶介导的还原反应的立体选择性的影响。开发了一个简单的模型来描述OYE1-3酶结合位点内底物最佳排列的结构前提。

  DOI：

  10.1039/c3cy20804d

文献信息

• Novel methods of imaging and treatment with targeted compositions
  申请人：——

  公开号：US20030157025A1

  公开（公告）日：2003-08-21

  Novel ultrasound methods comprising administering to a patient a targeted vesicle composition which comprises vesicles comprising a lipid, protein or polymer, encapsulating a gas, in combination with a targeting ligand, and scanning the patient using ultrasound. The scanning may comprise exposing the patient to a first type of ultrasound energy and then interrogating the patient using a second type of ultrasound energy. The targeting ligand preferably targets tissues, cells or receptors, including myocardial cells, endothelial cells, epithelial cells, tumor cells and the glycoprotein GPIIbIIIa receptor. The methods may be used to detect a thrombus, enhancement of an old or echogenic thrombus, low concentrations of vesicles and vesicles targeted to tissues, cells or receptors.

  新型超声波方法包括向患者施加含有脂质、蛋白质或聚合物的气囊组成的有针对性的气囊组合物，该气囊包含一种气体，并与一个靶向配体结合，然后使用超声波扫描患者。扫描可能包括将患者暴露于第一种超声波能量，然后使用第二种超声波能量对患者进行询问。靶向配体首选靶向组织、细胞或受体，包括心肌细胞、内皮细胞、上皮细胞、肿瘤细胞和糖蛋白GPIIbIIIa受体。该方法可用于检测血栓、旧血栓或回声增强、低浓度气囊和靶向组织、细胞或受体的气囊。
• Surgical adhesive
  申请人：SANYO CHEMICAL INDUSTRIES LTD.

  公开号：EP0332405A2

  公开（公告）日：1989-09-13

  Elastomeric or flexible surgical adhesives, arising [A] NCO-­tested hydrophilic urethane prepolymer derived from fluorine-­containing polyisocyanate and hydrophilic polyether polyol of higher oxyethylene content, or combination of [A] with [B] unsaturated cyano compound containing cyano group attached to a carbon atom constituting the polyerizable double bond, are of lower toxicity and used with safety for bonding of tissues, with rapid cure rate and sufficient bonding power.

  由含氟多异氰酸酯和氧乙烯含量较高的亲水性聚醚多元醇衍生的[A]经 NCO 测试的亲水性聚氨酯预聚物，或[A]与[B]不饱和氰基化合物（含有连接到构成可聚合双键的碳原子上的氰基）组合而成的弹性或柔性外科粘合剂毒性较低，可安全用于粘合组织，具有快速固化率和足够的粘合力。
• Novel targeted compositions for diagnostic and therapeutic use
  申请人：IMARX PHARMACEUTICAL CORP.

  公开号：EP1444991A1

  公开（公告）日：2004-08-11

  Novel targeted compositions which may be used for diagnostic and therapeutic use. The compositions may comprise a lipid, a protein or a polymer and a gas, in combination with a targeting ligand. The targeting ligand targets tissues, cells or receptors, including myocardial cells, endothelial cells, epithelial cells, tumour cells and the glycoprotein GPIIbIIIa receptor. The contrast media can be used in conjunction with diagnostic imaging, such as ultrasound, as well as therapeutic applications, such as therapeutic ultrasound.

  可用于诊断和治疗的新型靶向组合物。这些组合物可由脂质、蛋白质或聚合物和气体与靶向配体组合而成。靶向配体靶向组织、细胞或受体，包括心肌细胞、内皮细胞、上皮细胞、肿瘤细胞和糖蛋白 GPIIbIIIa 受体。造影剂可与超声波等诊断成像和治疗超声波等治疗应用结合使用。
• OPTICAL MEMBER SET AND SOLID-STATE IMAGE PICKUP ELEMENT USING SAME
  申请人：FUJI-FILM Corporation

  公开号：EP2799912A1

  公开（公告）日：2014-11-05

  An optical member set which has a first optical member formed by curing a curable resin composition, and a second optical member which is covered by the first optical member, in which the first optical member has a refractive index of 1.25 to 1.45 and the second optical member has a refractive index of 1.65 to 1.95.

  一种光学元件组，它具有通过固化可固化树脂组合物形成的第一光学元件和被第一光学元件覆盖的第二光学元件，其中第一光学元件的折射率为 1.25 至 1.45，第二光学元件的折射率为 1.65 至 1.95。
• OPTICAL MEMBER SET AND SOLID-STATE IMAGE SENSOR USING SAME
  申请人：FUJI-FILM Corporation

  公开号：EP2799913A1

  公开（公告）日：2014-11-05

  An optical member set which has a first optical member formed by curing a composition of curable resins, and a second optical member which is covered by the first optical member, in which the contact angle with water on a surface, which comes into contact with a first optical member, of the second optical member is 70 to 97° and the contact angle with the water on a surface of the opposite side to the side, which comes into contact with the second optical member, of the first optical member is 80 to 115°.

  一种光学元件组，它具有通过固化可固化树脂组合物形成的第一光学元件，以及被第一光学元件覆盖的第二光学元件，其中第二光学元件与第一光学元件接触的表面与水的接触角为 70 至 97°，而与第一光学元件接触的第二光学元件相反一侧表面与水的接触角为 80 至 115°。