1-Azido-3-tert-butoxy-propan-2-ol | 174500-45-9

• 分子结构分类: 有机化合物 - 有机1,3-偶极化合物 - 烯丙基型1,3-偶极有机化合物
• 英文名称: 1-Azido-3-tert-butoxy-propan-2-ol
• 英文别名: 2-Propanol, 1-azido-3-(1,1-dimethylethoxy)-；1-azido-3-[(2-methylpropan-2-yl)oxy]propan-2-ol
• CAS: 174500-45-9
• 化学式: C₇H₁₅N₃O₂
• 分子量: 173.215
• InChiKey: PLDPUHAGNUKTFO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  43.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  乙酸乙烯酯 、 1-Azido-3-tert-butoxy-propan-2-ol 以45%的产率得到Acetic acid (R)-1-azidomethyl-2-tert-butoxy-ethyl ester
  参考文献：
  名称：

  The efficient resolution of protected diols and hydroxy aldehydes by lipases: steric auxiliary approach and synthetic applications

  摘要：

  1,n-Diols (n = 2 - 5) and 2-hydroxy aldehydes protected with a steric auxiliary are transformed by Pseudomonas lipases with high enantioselectivity, thus allowing the efficient resolution of these molecules and the synthesis of related derivatives with high optical purity.

  DOI：

  10.1016/0960-894x(95)00550-d

文献信息

• The efficient resolution of protected diols and hydroxy aldehydes by lipases: steric auxiliary approach and synthetic applications
  作者：Mahn-Joo Kim、In Taek Lim、Gil-Bae Choi、Sang-Yeul Whang、Bon-Cheol Ku、Jin-Young Choi

  DOI：10.1016/0960-894x(95)00550-d

  日期：1996.1

  1,n-Diols (n = 2 - 5) and 2-hydroxy aldehydes protected with a steric auxiliary are transformed by Pseudomonas lipases with high enantioselectivity, thus allowing the efficient resolution of these molecules and the synthesis of related derivatives with high optical purity.