(12S,16R)-7,10-Diazatetracyclo[8.6.1.05,17.012,16]heptadeca-1,3,5(17)-triene | 620948-93-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: (12S,16R)-7,10-Diazatetracyclo[8.6.1.05,17.012,16]heptadeca-1,3,5(17)-triene
• CAS: 620948-93-8
• 化学式: C₁₅H₂₀N₂
• 分子量: 228.33
• InChiKey: NPTIPEQJIDTVKR-CHWSQXEVSA-N

物化性质

• 密度：
  1.16

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• CHIRAL SYNTHESIS OF DIAZEPINOQUINOLINES
  申请人：Megati Sreenivasulu

  公开号：US20090093630A1

  公开（公告）日：2009-04-09

  The present invention relates to improved methods of resolution and recrystallization for synthesizing compounds useful as 5HT 2C agonists or partial agonists, including intermediates thereto.

  本发明涉及改进的分解和再结晶方法，用于合成作为5HT2C受体激动剂或部分激动剂有用的化合物，包括其中间体。
• [EN] CHIRAL SYNTHESIS OF DIAZEPINOQUINOLINES<br/>[FR] SYNTHÈSE CHIRALE DE DIAZÉPINOQUINOLINES
  申请人：WYETH CORP

  公开号：WO2009039362A2

  公开（公告）日：2009-03-26

  The present invention relates to improved methods of resolution and recrystallization for synthesizing compounds of formulae (I-1) or (A) useful as 5HT2 agonists or partial agonists, including intermediates thereto.

  本发明涉及改进的分离和重结晶方法，用于合成式（I-1）或（A）化合物，这些化合物是5HT2激动剂或部分激动剂，包括其中间体。
• Treatment of substance abuse
  申请人：Rosenzweig-Lipson Sharon

  公开号：US20070167438A1

  公开（公告）日：2007-07-19

  The present invention provides methods and compositions for use in the treatment, prevention, and/or alleviation of drug abuse and/or its symptoms. In particular, the invention demonstrates that compositions comprising compounds of formula I are useful in such treatment, prevention, and/or alleviation: or a pharmaceutically acceptable salt thereof, wherein each of n, R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are as defined herein.