Technetium Tc 99m mebrofenin | 1415247-71-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Technetium Tc 99m mebrofenin
• 英文别名: 2-[[2-(3-bromo-2,4,6-trimethylanilino)-2-oxoethyl]-(carboxymethyl)amino]acetic acid;technetium-99
• CAS: 1415247-71-0
• 化学式: C15H19BrN2O5Tc
• 分子量: 486.13
• InChiKey: JLJSYHOPCNWUNE-IEOVAKBOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.78
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  107
• 氢给体数：
  3
• 氢受体数：
  6

ADMET

毒理性

• 在妊娠和哺乳期间的影响

哺乳期使用总结：本记录中的信息指的是作为诊断剂使用的锝Tc 99m美布酚。目前没有关于哺乳期间使用锝Tc 99m美布酚的信息。美国核能管理委员会的一个小组委员会建议，为了简化指导建议，所有锝Tc 99m诊断产品给药后应停止哺乳24小时，尽管这个时间间隔可能比必要的要长。一些专家建议在给予放射性药物前哺乳婴儿，并在剂量后中断哺乳4到12小时，然后完全挤出一次乳汁并丢弃。如果母亲在检查前已经挤出并保存了乳汁，她可以在哺乳中断期间给婴儿喂食。母亲在常规临床剂量后不必避免与婴儿密切接触。 担心乳汁中放射性水平的母亲可以要求在医院核医学科进行检测。当放射性水平达到背景水平时，她们可以安全地恢复哺乳。已经发布了一种测量乳汁放射性和确定母亲可以安全恢复哺乳的时间的方法。 对于在工作场所接触Tc 99m物质的哺乳期母亲，除了适当的辐射防护措施外，无需采取任何预防措施。 ◉ 对哺乳婴儿的影响：截至修订日期，未找到相关已发布信息。 ◉ 对哺乳和乳汁的影响：截至修订日期，未找到相关已发布信息。

◉ Summary of Use during Lactation:Information in this record refers to the use of technetium Tc 99m mebrofenin as a diagnostic agent. No information is available on the use of technetium Tc 99m mebrofenin during breastfeeding . A US Nuclear Regulatory Commission subcommittee has recommended that nursing be discontinued for 24 hours after administration of all technetium Tc 99m diagnostic products to simplify guidance recommendations, although this time interval may be longer than necessary. Some experts recommend nursing the infant just before administration of the radiopharmaceutical and interrupting breastfeeding for 4 to 12 hours after the dose, then expressing the milk completely once and discarding it. If the mother has expressed and saved milk prior to the examination, she can feed it to the infant during the period of nursing interruption. Mothers need not refrain from close contact with their infants after usual clinical doses. Mothers concerned about the level of radioactivity in their milk could ask to have it tested at a nuclear medicine facility at their hospital. When the radioactivity is at background levels they may safely resume breastfeeding. A method for measuring milk radioactivity and determining the time when a mother can safely resume breastfeeding has been published. For nursing mothers who work with Tc 99m substances in their workplace, there is no need to take any precautions other than those appropriate for general radiation protection. ◉ Effects in Breastfed Infants:Relevant published information was not found as of the revision date. ◉ Effects on Lactation and Breastmilk:Relevant published information was not found as of the revision date.

来源:Drugs and Lactation Database (LactMed)

吸收、分配和排泄

• 吸收

在肝脏中，可视化可以在注射后5分钟内检测到，最大肝脏摄取发生在注射后11分钟。对于肝胆管和胆囊的可视化，在10到15分钟内发生，而在正常肝胆功能的受试者中，肠道活动在30到60分钟内可视化。在10分钟时，血液中剩余的平均注射剂量百分比为17%。

Visualisation in the liver could be detected by 5 minutes and maximum liver uptake occurred at 11 minutes post-injection. Hepatic duct and gallbladder visualization occurred by 10 to 15 minutes and intestinal activity was visualized by 30 to 60 minutes in subjects with normal hepatobiliary function The mean percent injected dose remaining in the blood at 10 minutes was 17%.

来源:DrugBank

吸收、分配和排泄

• 消除途径

在最初的3小时内，平均尿液中排出的注射剂量百分比是1%。

The mean percent injected dose excreted in the urine during the first 3 hours was 1%.

来源:DrugBank

吸收、分配和排泄

• 清除

在正常受试者中静脉给药后，锝[99mTc]美布酚迅速从循环中清除。

Following intravenous administration in normal subjects, Technetium Tc 99m Mebrofenin was rapidly cleared from the circulation.

来源:DrugBank