Dioctylmalonyl Dichloride | 318960-59-7

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 酰卤
• 英文名称: Dioctylmalonyl Dichloride
• 英文别名: 2,2-Dioctylpropanedioyl dichloride
• CAS: 318960-59-7
• 化学式: C₁₉H₃₄Cl₂O₂
• 分子量: 365.384
• InChiKey: BNPRFODSWDWWBD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.6
• 重原子数：
  23
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Dioctylmalonyl Dichloride 在 4-二甲氨基吡啶 、 Dowex 50W 、 三乙胺 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 生成 N¹,N³-bis-(1-deoxy-D-galactitol-1-yl)-2,2-dioctylmalonamide
  参考文献：
  名称：

  Neimert-Andersson, Kristina; Blomberg, Eva; Somfai, Peter, Journal of Organic Chemistry, 2004, vol. 69, # 11, p. 3746 - 3752

  摘要：

  DOI：
• 作为产物：
  描述：

  dimethyl 2,2-dioctylmalonate 在 氢氧化钾 、 草酰氯 、 N,N-二甲基甲酰胺 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 反应 101.0h， 生成 Dioctylmalonyl Dichloride
  参考文献：
  名称：

  Neimert-Andersson, Kristina; Blomberg, Eva; Somfai, Peter, Journal of Organic Chemistry, 2004, vol. 69, # 11, p. 3746 - 3752

  摘要：

  DOI：

文献信息

• Synthesis of a tetraamido macrocycle ligand from a novel diamidodiol
  申请人：The Clorox Company

  公开号：US06384279B1

  公开（公告）日：2002-05-07

  A new composition of matter for a diamidodiol and a method for preparing the diamidodiol. The exemplary diamidodiol has the formula C15H30N2O4 and is prepared by reacting a first quantity of 2-amino-2-methyl-1-propanol with a second quantity of a di-substituted malonyl dichloride (i.e., diethylmalonyl dichloride), preferably in ethyl acetate as solvent. A tetraamido macrocycle is prepared from the diamidodiol in two steps by oxidizing the diamidodiol to form a diacid followed by coupling using a known procedure of the diacid with an aryl diamine (e.g., 1,2-diaminobenzene) to yield the tetraamido macrocycle.

  一种新的二酰胺二醇物质及其制备方法。示例的二酰胺二醇的化学式为C15H30N2O4，通过将一定量的2-氨基-2-甲基-1-丙醇与二取代马来酰二氯化物（即二乙基马来酰二氯化物）在乙酸乙酯溶剂中反应制备而成。通过氧化二酰胺二醇形成二酸，然后使用已知的程序将二酸与芳香族二胺（例如1,2-二氨基苯）偶联，制备四酰胺大环。
• SYNTHESIS OF A TETRAAMIDO MACROCYCLE LIGAND FROM A NOVEL DIAMIDODIOL
  申请人：THE CLOROX COMPANY

  公开号：US20020028970A1

  公开（公告）日：2002-03-07

  A new composition of matter for a diamidodiol and a method for preparing the diamidodiol. The exemplary diamidodiol has the formula C 15 H 30 N 2 O 4 and is prepared by reacting a first quantity of 2-amino-2-methyl-1-propanol with a second quantity of a di-substituted malonyl dichloride (i.e., diethylmalonyl dichloride), preferably in ethyl acetate as solvent. A tetraamido macrocycle is prepared from the diamidodiol in two steps by oxidizing the diamidodiol to form a diacid followed by coupling using a known procedure of the diacid with an aryl diamine (e.g., 1 ,2-diaminobenzene)to yield the tetraamido macrocycle.

  一种新的二酰胺二醇物质组合及其制备方法。示例的二酰胺二醇的化学式为C15H30N2O4，通过将第一量的2-氨基-2-甲基-1-丙醇与第二量的二取代马隆酰二氯化物（即二乙酰马隆酰二氯化物）在乙酸乙酯溶剂中反应制备而成。通过将二酰胺二醇氧化形成二酸，然后使用已知的方法将二酸与芳基二胺（例如1,2-二氨基苯）偶联，制备出四酰胺大环。
• [EN] IMPROVED SYNTHESIS OF A TETRAAMIDO MACROCYCLE LIGAND FROM A NOVEL DIAMIDODIOL<br/>[FR] SYNTHESE AMELIOREE D'UN LIGAND TETRA-AMIDO MACROCYCLIQUE A PARTIR D'UN NOUVEAU DIAMIDODIOL
  申请人：CLOROX CO

  公开号：WO2001002343A1

  公开（公告）日：2001-01-11

  A new composition of matter for a diamidodiol and a method for preparing the diamidodiol. The exemplary diamidodiol has the formula C15H30N2O4 and is prepared reacting a first quantity of 2-amino-2-methyl-1-propanol with a second quantity of a disubstituted malonyl dichloride (i.e., diethylmalonyl dichloride), preferably in ethyl acetate as solvent. A tetraamido macrocylce is prepared from the diamidodiol in two steps by oxidizing the diamidodiol to form a diacid followed by coupling using a known procedure of the diacid with an aryl diamine (e.g., 1,2-diaminobenzene) to yield the tetraamido macrocylcle.
• Neimert-Andersson, Kristina; Blomberg, Eva; Somfai, Peter, Journal of Organic Chemistry, 2004, vol. 69, # 11, p. 3746 - 3752
  作者：Neimert-Andersson, Kristina、Blomberg, Eva、Somfai, Peter

  DOI：——

  日期：——