2,2,2-trifluoro-N-[4-nitro-2-[(2,2,2-trifluoroacetyl)amino]phenyl]acetamide | 23564-20-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,2,2-trifluoro-N-[4-nitro-2-[(2,2,2-trifluoroacetyl)amino]phenyl]acetamide
• CAS: 23564-20-7
• 化学式: C₁₀H₅F₆N₃O₄
• 分子量: 345.158
• InChiKey: LOYXEYDNMWXSSE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  104
• 氢给体数：
  2
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  4-硝基邻苯二胺 、 三氟乙酸酐 以 四氢呋喃 为溶剂， 反应 0.03h， 以94%的产率得到2,2,2-trifluoro-N-[4-nitro-2-[(2,2,2-trifluoroacetyl)amino]phenyl]acetamide
  参考文献：
  名称：

  N-Trifluoroacétylation sélective d'ortho-arylènediamines sous ultrasons

  摘要：

  Mono and di-N-trifluoroacetylation of ortho-arylenediamines can be performed selectively under ultrasound irradiation according to the relative amounts of starting materials. Mono and di-trifluoroacetylated compounds 3 and 4 are prepared with good yields in dry THF during 1 to 2 min sonication. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)00723-1

文献信息

• FLUOROALKYLATING AGENT
  申请人：IHARA CHEMICAL INDUSTRY CO., LTD.

  公开号：US20170197920A1

  公开（公告）日：2017-07-13

  Problem to be Solved It is intended to provide an industrially preferable fluoroalkylating agent and use thereof. Solution The present invention provides a fluoroalkylating agent represented by the general formula (1) wherein R 1 is a C1 to C8 fluoroalkyl group; R 2 and R 3 are each independently a C1 to C12 alkyl group or the like; Y 1 to Y 4 are each independently a hydrogen atom, a halogen atom, or the like; and X − is a monovalent anion. A compound of the general formula (3): R 4 —S—R 1 having an introduced C1 to C8 fluoroalkyl group is easily obtained by reacting a compound of the general formula (2): R 4 —S—Z wherein R 4 is a hydrocarbon group or the like; and Z is a leaving group, with the compound of the general formula (1).

  要解决的问题 旨在提供一种工业上可取的氟烷基化剂及其使用方法。 解决方案 本发明提供了一种由通式（1）表示的氟烷基化剂，其中R 1 是C1到C8的氟烷基团；R 2 和R 3 分别独立地是C1到C12的烷基团或类似物；Y 1 到Y 4 分别独立地是氢原子、卤素原子或类似物；X − 是一价阴离子。 通式（3）的化合物：R 4 —S—R 1 ，其中引入了C1到C8的氟烷基团，可通过将通式（2）的化合物：R 4 —S—Z（其中R 4 是烃基团或类似物；Z是离去基团）与通式（1）的化合物反应而轻松获得。
• Fluoroalkylating agent
  申请人：KUMIAI CHEMICAL INDUSTRY CO., LTD.

  公开号：US10308613B2

  公开（公告）日：2019-06-04

  Problem to be Solved It is intended to provide an industrially preferable fluoroalkylating agent and use thereof. Solution The present invention provides a fluoroalkylating agent represented by the general formula (1) wherein R1 is a C1 to C8 fluoroalkyl group; R2 and R3 are each independently a C1 to C12 alkyl group or the like; Y1 to Y4 are each independently a hydrogen atom, a halogen atom, or the like; and X− is a monovalent anion. A compound of the general formula (3): R4—S—R1 having an introduced C1 to C8 fluoroalkyl group is easily obtained by reacting a compound of the general formula (2): R4—S—Z wherein R4 is a hydrocarbon group or the like; and Z is a leaving group, with the compound of the general formula (1).

  有待解决的问题 旨在提供一种工业上更理想的氟烷基化剂及其用途。 解决方案 本发明提供了一种由通式（1）表示的氟烷基化剂，其中 R1 是 C1 至 C8 氟烷基；R2 和 R3 各自独立地是 C1 至 C12 烷基或类似基团；Y1 至 Y4 各自独立地是氢原子、卤素原子或类似基团；X- 是单价阴离子。 通式（3）的化合物：将通式（2）的化合物与通式（1）的化合物反应，很容易得到具有引入的 C1 至 C8 氟烷基的 R4-S-R1 化合物：其中 R4 是烃基或类似物；Z 是离去基团。
• N-Trifluoroacétylation sélective d'ortho-arylènediamines sous ultrasons
  作者：Khalid Bougrin、André Loupy、Alain Petit、Rachid Benhida、Jean-Louis Fourrey、Boujemâa Daou、Mohamed Soufiaoui

  DOI：10.1016/s0040-4039(00)00723-1

  日期：2000.6

  Mono and di-N-trifluoroacetylation of ortho-arylenediamines can be performed selectively under ultrasound irradiation according to the relative amounts of starting materials. Mono and di-trifluoroacetylated compounds 3 and 4 are prepared with good yields in dry THF during 1 to 2 min sonication. (C) 2000 Elsevier Science Ltd. All rights reserved.