(2R,7R)-7-hydroxy-2-propyloctanoic acid | 824961-08-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: (2R,7R)-7-hydroxy-2-propyloctanoic acid
• CAS: 824961-08-2
• 化学式: C₁₁H₂₂O₃
• 分子量: 202.294
• InChiKey: JEOQOWYMMPYUAH-NXEZZACHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  14
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Branched carboxylic acid compound and use thereof
  申请人：Imawaka Haruo

  公开号：US20070167522A1

  公开（公告）日：2007-07-19

  The present invention relates to a compound represented by formula (I) wherein R 1 represents optionally protected hydroxy or oxo, indicates α-configuration, β-configuration or a mixture of these in an arbitary proportion, n represents an integer of 1 to 3, and m represents 0 or an integer of 1 to 10; and wherein two or more R 1 's are not bound to the same carbon atom other than the terminal carbon atom, a salt thereof or a prodrug thereof. The compounds represented by formula (I) have an ability to improve astrocyte function, and they are useful as a preventive and/or therapeutic agent for a brain infarction, neuronal dysfunction by brain infarction, Parkinson's disease, Parkinson's syndrome, amyotrophic lateral sclerosis or Alzheimer's disease.

  本发明涉及一种由式(I)表示的化合物，其中R1表示可选择保护的羟基或酮基，表示α构型、β构型或任意比例的混合物，n表示1到3的整数，m表示0或1到10的整数；其中两个或多个R1未与终端碳原子以外的同一碳原子结合，其盐或前药。式(I)表示的化合物具有改善星形胶质细胞功能的能力，它们可用作预防和/或治疗脑梗死、脑梗死引起的神经功能障碍、帕金森病、帕金森综合症、肌萎缩性侧索硬化或阿尔茨海默病的药物。
• NERVE REGENERATION PROMOTERS
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP1685832A1

  公开（公告）日：2006-08-02

  A nerve regeneration which comprises a compound is represented by formula (I): (wherein all symbols are shown in the description), a salt thereof or a prodrug thereof. The compound of the present invention is suppresses nerve cell death as a substance for accelerating growth and/or differentiation of stem cells (nerve stem cells, embryonic stem cells, bone marrow cells, etc.), a substance for accelerating growth and/or differentiation of nerve precursor cells, a potentiator for neurotrophic factor activity, a neurotrophic factor-like substance or a neurodegenerative suppressor, and accelerates repair and regeneration of nerve tissues by neogenesis, regeneration and/or axon evolution. In addition, the compound of the present invention is useful for preparation from brain tissues, bone marrow and/or embryonic stem cells of cells for transplant (nerve stem cells, nerve precursor cells, nerve cells, etc.) and also accelerates grafting, growth, differentiation and/or function expression of cells for transplant whereupon it is useful for prevention and/or treatment of neurodegenerative diseases.

  由式 (I) 所表示的化合物组成的神经再生剂： (其中所有符号均在描述中显示）、其盐或其原药。本发明化合物可抑制神经细胞死亡，可作为加速干细胞（神经干细胞、胚胎干细胞、骨髓细胞等）生长和/或分化的物质、加速神经前体细胞生长和/或分化的物质、神经营养因子活性增效剂、神经营养因子样物质或神经退行性抑制剂，并通过新生、再生和/或轴突演化加速神经组织的修复和再生。此外，本发明的化合物可用于从脑组织、骨髓和/或胚胎干细胞中制备移植细胞（神经干细胞、神经前体细胞、神经细胞等），还可加速移植细胞的移植、生长、分化和/或功能表达，从而可用于预防和/或治疗神经退行性疾病。
• BRANCHED CARBOXYLIC ACID COMPOUND AND USE THEREOF
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP1650182B1

  公开（公告）日：2009-10-07
• Nerve regeneration promoters
  申请人：Tateishi Narito

  公开号：US20070043114A1

  公开（公告）日：2007-02-22

  A nerve regeneration which comprises a compound is represented by formula (I): (wherein all symbols are shown in the description), a salt thereof or a prodrug thereof. The compound of the present invention is suppresses nerve cell death as a substance for accelerating growth and/or differentiation of stem cells (nerve stem cells, embryonic stem cells, bone marrow cells, etc.), a substance for accelerating growth and/or differentiation of nerve precursor cells, a potentiator for neurotrophic factor activity, a neurotrophic factor-like substance or a neurodegenerative suppressor, and accelerates repair and regeneration of nerve tissues by neogenesis, regeneration and/or axon evolution. In addition, the compound of the present invention is useful for preparation from brain tissues, bone marrow and/or embryonic stem cells of cells for transplant (nerve stem cells, nerve precursor cells, nerve cells, etc.) and also accelerates grafting, growth, differentiation and/or function expression of cells for transplant whereupon it is useful for prevention and/or treatment of neurodegenerative diseases.
• US7579375B2
  申请人：——

  公开号：US7579375B2

  公开（公告）日：2009-08-25