N^ε-carboxyethyllysine | 18120-67-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N^ε-carboxyethyllysine
• 英文别名: N(6)-(2-carboxyethyl)-L-lysine；(2S)-2-amino-6-(2-carboxyethylamino)hexanoic acid
• CAS: 18120-67-7
• 化学式: C₉H₁₈N₂O₄
• 分子量: 218.253
• InChiKey: SPBWCBIQZFYDOE-ZETCQYMHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.3
• 重原子数：
  15
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  113
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• Detection and Treatment of Schizophrenia
  申请人：Itokawa Masanari

  公开号：US20110028470A1

  公开（公告）日：2011-02-03

  The present invention provides a method for diagnosing schizophrenia, and a schizophrenia diagnostic reagent or device for use in the method. The present invention further provides a therapeutic or ameliorating agent for schizophrenia, which is effective for the treatment or amelioration of schizophrenia. The therapeutic or ameliorating agent for schizophrenia contains a carbonyl scavenger or a carbonyl-modified protein formation inhibitor as an active ingredient. The method for diagnosing schizophrenia according to the present invention includes measuring at least one parameter in a subject, the parameter being selected from the group consisting of: (1) a genetic abnormality of glyoxalase I gene; (2) the expression level or activity of glyoxalase I in a biological sample; (3) the amount of a carbonyl compound or a carbonyl-modified protein that is a protein modified with the carbonyl compound; and (4) the amount of pyridoxal in a biological sample.

  本发明提供了一种用于诊断精神分裂症的方法，以及用于该方法的精神分裂症诊断试剂或设备。本发明进一步提供了一种治疗或改善精神分裂症的药剂，该药剂对于治疗或改善精神分裂症有效。用于治疗或改善精神分裂症的药剂包含醛固定剂或醛修饰蛋白形成抑制剂作为活性成分。根据本发明的诊断精神分裂症的方法包括在受试者中测量至少一个参数，所述参数选自以下组合：（1）甘氧化酶I基因的遗传异常；（2）生物样本中甘氧化酶I的表达水平或活性；（3）蛋白质中醛化合物或经醛化合物修饰的蛋白质的量；以及（4）生物样本中吡哆醛的量。
• DETECTION AND TREATMENT OF SCHIZOPHRENIA
  申请人：TOKAI UNIVERSITY EDUCATIONAL SYSTEM

  公开号：EP2189537A1

  公开（公告）日：2010-05-26

  The present invention provides a method for diagnosing schizophrenia, and a schizophrenia diagnostic reagent or device for use in the method. The present invention further provides a therapeutic or ameliorating agent for schizophrenia, which is effective for the treatment or amelioration of schizophrenia. The therapeutic or ameliorating agent for schizophrenia contains a carbonyl scavenger or a carbonyl-modified protein formation inhibitor as an active ingredient. The method for diagnosing schizophrenia according to the present invention includes measuring at least one parameter in a subject, the parameter being selected from the group consisting of: (1) a genetic abnormality of glyoxalase I gene; (2) the expression level or activity of glyoxalase I in a biological sample; (3) the amount of a carbonyl compound or a carbonyl-modified protein that is a protein modified with the carbonyl compound; and (4) the amount of pyridoxal in a biological sample.

  本发明提供了一种诊断精神分裂症的方法，以及一种用于该方法的精神分裂症诊断试剂或装置。本发明进一步提供了一种治疗或改善精神分裂症的药剂，该药剂可有效治疗或改善精神分裂症。精神分裂症的治疗剂或改善剂含有羰基清除剂或羰基修饰蛋白形成抑制剂作为活性成分。根据本发明的诊断精神分裂症的方法包括测量受试者体内的至少一个参数，该参数选自由以下组成的组：(1)乙二醛酶I基因的遗传异常；(2)生物样本中乙二醛酶I的表达水平或活性；(3)羰基化合物或羰基修饰蛋白的量，该蛋白是用羰基化合物修饰的蛋白；(4)生物样本中吡哆醛的量。
• Detection and treatment of schizophrenia
  申请人：TOKAI UNIVERSITY EDUCATIONAL SYSTEM

  公开号：EP2662453A2

  公开（公告）日：2013-11-13

  The present invention relates to a method for diagnosing schizophrenia comprising measuring at least one parameter in a subject, the parameter being selected from the group consisting of (1) a genetic abnormality of glyoxalase I gene, (2) the expression level or activity of glyoxalase I in a biological sample, (3) the amount of a carbonyl-modified protein that is a protein modified with the carbonyl-compound, preferably pentosidine, in a biological sample, and (4) the amount of pyridoxal in a biological sample. The present further relates to a primer, a probe and a reagent for use in said method, as well as an AGE-reader and its use for measuring the amount of carbonyl-modified proteins.

  本发明涉及一种诊断精神分裂症的方法，该方法包括测量受试者体内的至少一个参数，该参数选自以下组别：(1)乙二醛酶 I 基因的遗传异常；(2)生物样本中乙二醛酶 I 的表达水平或活性；(3)生物样本中羰基修饰蛋白质的量，该蛋白质是用羰基化合物（最好是喷托西啶）修饰的蛋白质；(4)生物样本中吡哆醛的量。本发明还涉及一种用于上述方法的引物、探针和试剂，以及一种 AGE 读取器及其在测量羰基修饰蛋白质量时的用途。
• ANTI-GLYCATION AGENT COMPRISING A GARCINIA KOLA EXTRACT OR FRACTION
  申请人：UNIVERSITE D'ANGERS

  公开号：EP2735312A1

  公开（公告）日：2014-05-28

  This invention relates to an anti-glycation agent comprising a Garcinia kola extract or fraction. The compositions comprising the extract or the fraction are used to inhibit the glycation of proteins, in particular the glycation of skin proteins involved in cutaneous aging. This invention also relates to a method for determining the activity of compounds for inhibiting the glycation of cutaneous proteins, in particular for inhibiting the glycation of collagen.

  本发明涉及一种抗糖化剂，包含一种加西可拉提取物或馏分。包含该提取物或馏分的组合物可用于抑制蛋白质的糖化，特别是参与皮肤老化的皮肤蛋白质的糖化。本发明还涉及一种确定抑制皮肤蛋白质糖化，特别是抑制胶原蛋白糖化的化合物活性的方法。
• PHARMACEUTICAL COMPOSITION COMPRISING MONOSACCHARIDE AND/OR POLYSACCHARIDE, AND MONOSACCHARIDE AND POLYSACCHARIDE FOR PRODUCING THE SAME
  申请人：Lee, Jen-Ai

  公开号：EP3067055A1

  公开（公告）日：2016-09-14

  The present invention discloses a pharmaceutical composition comprising a monosaccharide and/or polysaccharide as an active ingredient thereof, for decreasing the accumulation of di-carbonyl compounds in the human body. Said monosaccharide is a monomer of said polysacchaiide, and the molecular weight of the polysaccharide ranges from 29 kDa to 36 kDa. The monosaccharide and/or polysaccharide can be used to prevent or treat nephritis or diseases associated with di-carbonyl compounds, or other diseases caused by carbonyl-stress, and can also be used to make the relevant drug.

  本发明公开了一种药物组合物，其活性成分包括单糖和/或多糖，用于减少二羰基化合物在人体内的积累。所述单糖是所述多糖的单体，多糖的分子量在 29 kDa 至 36 kDa 之间。所述单糖和/或多糖可用于预防或治疗肾炎或与二羰基化合物有关的疾病，或其他由羰基应激引起的疾病，也可用于制造相关药物。