5,7-dihydroxy-6-undecanone | 649767-32-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 5,7-dihydroxy-6-undecanone
• 英文别名: 6-Undecanone, 5,7-dihydroxy-；5,7-dihydroxyundecan-6-one
• CAS: 649767-32-8
• 化学式: C₁₁H₂₂O₃
• 分子量: 202.294
• InChiKey: YQPIBVOFTROYMF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  14
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  5,7-Diiodo-undecan-6-one 在 三乙胺 、 potassium iodide 作用下， 以 丙酮 为溶剂， 反应 6.0h， 以73%的产率得到5,7-dihydroxy-6-undecanone
  参考文献：
  名称：

  A novel synthesis of α-hydroxy- and α,α′-dihydroxyketone from α-iodo and α,α′-diiodo ketone using photoirradiation

  摘要：

  A novel reaction of alpha-iodo ketone (alpha-iodocycloalkanone, alpha-iodo-beta-alkoxy ester, and alpha-iodoacyclicketone) with irradiation under a high-pressure mercury lamp gave the corresponding alpha-hydroxyketone in good yields. In the case of alpha,alpha'-diiodo ketone, alpha,alpha'-dihydroxyketone which little has been reported until now was obtained. This reaction affords a new, clean and convenient synthetic method for alpha-hydroxy- and alpha,alpha'-dihydroxyketone. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2003.10.082

文献信息

• [EN] REARRANGEMENT OF DIMETHYLPHENYLACYLATES USING ZEOLITES<br/>[FR] RÉARRANGEMENT DE DIMÉTHYLPHÉNYLACYLATES À L'AIDE DE ZÉOLITES
  申请人：DSM IP ASSETS BV

  公开号：WO2021156214A1

  公开（公告）日：2021-08-12

  The present invention relates to a Fries rearrangement of specific dimethylphenylacylates to form the desired respective hydroxyaryl ketones having two methyl groups bound to the aromatic ring. It has been found that the process is surprisingly very specific in view of the number and position of the methyl group(s) bound to the aromatic ring.

  本发明涉及一种特定二甲基苯基酰酸酯的弗莱重排反应，以形成所需的具有两个甲基基团结合在芳环上的羟基芳基酮。发现该过程在考虑结合在芳环上的甲基基团的数量和位置时具有惊人的特异性。
• [EN] PROCESS FOR THE PURIFICATION OF HYDROXYARYL-ALDHYDES AND KETONES AND THEIR USE IN THE PRODUCTION OF HYDROXYARYL OXIME DERIVATIVES<br/>[FR] PROCESSUS DE PURIFICATION D'HYDROXYARYL ALDEHYDES ET CETONES ET LEUR UTILISATION DANS LA PRODUCTION DE DERIVES D'HYDROXYARYL OXIME
  申请人：CYTEC TECH CORP

  公开号：WO2004054954A1

  公开（公告）日：2004-07-01

  A process for the purification of hydroxyaryl aldehydes and ketones comprising the following steps; 1) adding a mineral acid to a first composition comprising a hydroxyaryl aldehyde or a hydroxyaryl ketone; 2) washing the mixture obtained in step 1 with water; 3) isolating a second composition comprising a hydroxyaryl aldehyde or a hydroxyaryl ketone from step 2.

  一种用于纯化羟基芳基醛和酮的过程，包括以下步骤：1）向包含羟基芳基醛或羟基芳基酮的第一组分中加入矿酸；2）用水洗涤步骤1中得到的混合物；3）从步骤2中分离出包含羟基芳基醛或羟基芳基酮的第二个组分。
• Optical parts and sulfur-containing poly (thio)ester (co)polymer
  申请人：——

  公开号：US20030204030A1

  公开（公告）日：2003-10-30

  A poly(thio)ester (co)polymer which comprises a repeating structural unit represented by the formula (1-A) as an essential structural unit: 1 [wherein R 11 is a divalent aliphatic hydrocarbon group which may contain at least one sulfur atom in a sulfide group; R 12 is a mono- or poly-cyclic aliphatic or aromatic dicarboxylic acid residue; and X 11 and X 12 are each independently an oxygen atom or sulfur atom, and when X 11 and X 12 are the oxygen atoms, R 11 is a divalent aliphatic hydrocarbon group containing at least one sulfur atom in the sulfide group]; and an optical component obtainable by molding the poly(thio)ester (co)polymer. The poly(thio)ester (co)polymer is excellent in transparency and optical characteristics (e.g., a higher refractive index, higher Abbe number, and lower birefringence), and has also good mechanical characteristics and thermal characteristics, and further is excellent in melt fluidity and injection moldability.

  一种聚（硫）酯（共）聚合物，其包括由公式（1-A）表示的重复结构单元作为必要的结构单元：1 [其中，R11是一个双价的脂肪族碳氢基团，可以在硫化物基团中含有至少一个硫原子；R12是一个单环或多环的脂肪族或芳香族二羧酸残基；X11和X12分别是氧原子或硫原子，当X11和X12是氧原子时，R11是一个含有至少一个硫原子的双价脂肪族碳氢基团]；以及通过模塑聚（硫）酯（共）聚合物获得的光学组件。该聚（硫）酯（共）聚合物在透明度和光学特性（例如更高的折射率、更高的阿贝数和更低的双折射率）方面表现出色，同时具有良好的机械特性和热特性，并且在熔融流动性和注塑性方面表现出色。
• Multifunction "Crown Complexes" from Amino Acids and Peptides for Skin and Hair Restoration
  申请人：Gupta K Shyam

  公开号：US20070099886A1

  公开（公告）日：2007-05-03

  This invention relates to Schiff's bases derived from amino acids and hydroxyaryl alkyl ketones, or a plant extract containing the same, having general chemical structure in FIG. 1 for topical application. This invention also relates to certain metal complex of said Schiff's bases, which have a crown-like appearance in their three-dimensional chemical structure, as in FIG. 2 . The Schiff's bases and their metal complexes of the present invention are useful for the modulation of metal-activated enzymes and metalloenzymes, such as Phenylalanine Hydroxylase, Tyrosine Transaminase, Phenylalanine Transaminase, Tyrosinase, various MMP (Matrix metalloproteases), Superoxide dismutase, 5-Alpha Reductase, and citrate lyase. These are further suitable for multifunctional topical methods for skin whitening, skin wrinkles reduction, skin antiaging, collagen synthesis, acne control, hair loss prevention, hair graying control, and facial oil control.

  本发明涉及从氨基酸和羟基芳基烷基酮衍生的席夫碱，或含有该类化合物的植物提取物，其具有图1中的一般化学结构，用于局部应用。本发明还涉及所述席夫碱的某些金属配合物，其在三维化学结构中呈冠状外观，如图2所示。本发明的席夫碱及其金属配合物对于调节金属活化酶和金属酶，例如苯丙氨酸羟化酶、酪氨酸转氨酶、苯丙氨酸转氨酶、酪氨酸酶、各种基质金属蛋白酶、超氧化物歧化酶、5α-还原酶和柠檬酸裂解酶具有用途。此外，它们还适用于多功能局部方法，如美白肌肤、减少皮肤皱纹、抗衰老、胶原蛋白合成、控制痤疮、预防脱发、控制白发和面部油脂控制。
• Hair Loss Prevention by Natural Amino Acid and Peptide Complexes
  申请人：GUPTA SHYAM K

  公开号：US20090253668A1

  公开（公告）日：2009-10-08

  This invention relates to certain skin and hair care agents of formula (I), derived from natural amino acids and peptides. These agents provide multi-functional treatment of enzyme-related skin, hair and scalp problems, for example, hair aging including premature hair loss and hair graying; male pattern baldness; hair loss from dandruff; alopecia; split ends, acne, darkened skin, dark circles around eyes, stretch marks, wrinkles and fine lines, loss of collagen, loss of skin pliability and combinations thereof:

  本发明涉及公式（I）的某些皮肤和头发护理剂，这些护理剂源自天然氨基酸和肽。这些护理剂提供多功能的酶相关皮肤、头发和头皮问题的治疗，例如，头发老化，包括过早脱发和白发；男性型脱发；头皮屑引起的脱发；脱发斑秃；分叉，痤疮，皮肤变黑，眼周黑眼圈，妊娠纹，皱纹和细纹，胶原蛋白流失，皮肤柔韧性流失和它们的组合：