tert-Butyl-[(1R,4R)-4-(diphenyl-phosphinoyl)-cyclohex-2-enyloxy]-diphenyl-silane | 1028285-26-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tert-Butyl-[(1R,4R)-4-(diphenyl-phosphinoyl)-cyclohex-2-enyloxy]-diphenyl-silane
• 英文别名: tert-butyl-[(1R,4R)-4-diphenylphosphorylcyclohex-2-en-1-yl]oxy-diphenylsilane
• CAS: 1028285-26-8
• 化学式: C₃₄H₃₇O₂PSi
• 分子量: 536.726
• InChiKey: OVGSPLNLUBZJRB-IZEXYCQBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.66
• 重原子数：
  38
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  tert-Butyl-[(1R,4R)-4-(diphenyl-phosphinoyl)-cyclohex-2-enyloxy]-diphenyl-silane 在 4-二甲氨基吡啶 、 偶氮二异丁腈 、 氢氟酸 、 三正丁基氢锡 作用下， 以 二氯甲烷 、 水 、 甲苯 为溶剂， 反应 28.5h， 生成 (4R,4aR,9bS,5S)-4-(diphenylphosphinoyl)-5-phenyl-2,3,4,4a,5,9b-hexahydro-1H-benzo[b]phosphindole 5-oxide
  参考文献：
  名称：

  Preparation of a rigid bicyclic diphosphine by radical cyclisation

  摘要：

  Bromodiphosphine oxide 3 was obtained from the selectively protected chiral diol 2 by the double [2.3]-sigmatropic shift of an intermediate phosphinite. The bromophosphine oxide derivative 3 was converted by radical cyclisation into rigid bicyclic diphosphine 1. The diphosphine 1 was characterised and tested as a ligand in several metal catalytic reactions. (C) 2001 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0957-4166(01)00123-9
• 作为产物：
  描述：

  (1R,6R)-6-[tert-butyl(diphenyl)silyl]oxycyclohex-2-en-1-ol 在 4-二甲氨基吡啶 、 t-butyl diphenylsilanol 作用下， 以 乙醚 、 甲苯 为溶剂， 反应 36.5h， 生成 tert-Butyl-[(1R,4R)-4-(diphenyl-phosphinoyl)-cyclohex-2-enyloxy]-diphenyl-silane
  参考文献：
  名称：

  Preparation of a rigid bicyclic diphosphine by radical cyclisation

  摘要：

  Bromodiphosphine oxide 3 was obtained from the selectively protected chiral diol 2 by the double [2.3]-sigmatropic shift of an intermediate phosphinite. The bromophosphine oxide derivative 3 was converted by radical cyclisation into rigid bicyclic diphosphine 1. The diphosphine 1 was characterised and tested as a ligand in several metal catalytic reactions. (C) 2001 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0957-4166(01)00123-9

文献信息

• Preparation of a rigid bicyclic diphosphine by radical cyclisation
  作者：Stéphane Demay、Matthias Lotz、Kurt Polborn、Paul Knochel

  DOI：10.1016/s0957-4166(01)00123-9

  日期：2001.4

  Bromodiphosphine oxide 3 was obtained from the selectively protected chiral diol 2 by the double [2.3]-sigmatropic shift of an intermediate phosphinite. The bromophosphine oxide derivative 3 was converted by radical cyclisation into rigid bicyclic diphosphine 1. The diphosphine 1 was characterised and tested as a ligand in several metal catalytic reactions. (C) 2001 Published by Elsevier Science Ltd.