12,12-Dibromo-N-(methylsulfonyl)-11-dodecenamide | 206052-03-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: 12,12-Dibromo-N-(methylsulfonyl)-11-dodecenamide
• 英文别名: 12,12-dibromo-N-methylsulfonyldodec-11-enamide
• CAS: 206052-03-1
• 化学式: C₁₃H₂₃Br₂NO₃S
• 分子量: 433.2
• InChiKey: BDCZFOHEQGRTBW-UHFFFAOYSA-N

物化性质

• 密度：
  1.494±0.06 g/cm3(Predicted)
• 溶解度：
  DMSO 中≤20mg/ml；二甲基甲酰胺中≤30mg/ml

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  20
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  71.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Methods of modulating angiogenesis and cancer cell proliferation
  申请人：Roman J. Richard

  公开号：US20050124618A1

  公开（公告）日：2005-06-09

  Methods for regulating angiogenesis by modulating the activity of 20-HETE are disclosed. Further disclosed are methods of inhibiting cancer and tumor cell growth by exposing the cancer and tumor cells to 20-HETE inhibitors.

  本研究公开了通过调节 20-HETE 活性来调节血管生成的方法。还公开了通过让癌症和肿瘤细胞接触 20-HETE 抑制剂来抑制癌症和肿瘤细胞生长的方法。
• Nutritional supplements for cardiovascular health
  申请人：Zimmerman Arthur Karl

  公开号：US20060228403A1

  公开（公告）日：2006-10-12

  An admixture containing as active ingredients omega-3 polyunsaturated fatty acids selected from eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and linoleic acid (LNA), curcumin, B complex vitamins selected from folic acid, B6 and B12, antioxidant vitamins selected as vitamin C and vitamin E and ubiquinone. This compound is being designed for the support of cardiovascular health.

  一种混合物，其活性成分包括欧米伽-3 多不饱和脂肪酸（选自二十碳五烯酸 (EPA)、二十二碳六烯酸 (DHA) 和亚油酸 (LNA)）、姜黄素、选自叶酸、B6 和 B12 的复合维生素、选自维生素 C 和维生素 E 的抗氧化维生素以及泛醌。该化合物旨在促进心血管健康。
• COMPOSITIONS AND METHODS FOR TREATING CANCER
  申请人：Georgia Regents Research Institute, Inc.

  公开号：US20160022614A1

  公开（公告）日：2016-01-28

  Compositions containing one or more COX inhibitors in combination with one or more antagonists of 20-HETE (20-hydroxyeicosatetraeonic acid), and optionally a pharmaceutically acceptable excipient are provided. Preferred compositions include rofecoxib in combination with HET 0016. The compositions have reduced side effects due to COX inhibitors. Methods for treating or inhibiting cancer using the disclosed compositions are also provided.
• US9480664B2
  申请人：——

  公开号：US9480664B2

  公开（公告）日：2016-11-01