Barettin | 104311-70-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Barettin
• 英文别名: 2-[3-[(2S,5Z)-5-[(6-bromo-1H-indol-3-yl)methylidene]-3,6-dioxopiperazin-2-yl]propyl]guanidine
• CAS: 104311-70-8
• 化学式: C₁₇H₁₉BrN₆O₂
• 分子量: 419.3
• InChiKey: YYFNNPXWRXQUPR-JVXNRYDGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  138
• 氢给体数：
  5
• 氢受体数：
  3

文献信息

• [EN] BARETTIN AND DERIVATIVES THEREOF FOR MEDICAL USE, IN PARTICULAR FOR THE TREATMENT OF DISEASES RELATED TO OXIDATIVE STRESS OR INFLAMMATION, AND FOR PRESERVING OR WASHING ORGANS<br/>[FR] BARETTINE ET DÉRIVÉS DE CELLE-CI POUR UTILISATION MÉDICALE, EN PARTICULIER POUR LE TRAITEMENT DE MALADIES ASSOCIÉES À UN STRESS OXYDATIF OU UNE INFLAMMATION, ET POUR PRÉSERVER OU LAVER DES ORGANES
  申请人：ABC BIOSCIENCE AS

  公开号：WO2014162010A1

  公开（公告）日：2014-10-09

  The present invention relates to compounds of formula(I) herein, which includes barettin and derivatives thereof, or any pharmaceutically acceptable salt thereof for use as a medicament. Further the present invention relates to same compounds for use in the treatment of diseases related to oxidative stress and the treatment of inflammatory diseases. Still another aspect of the present invention is the use of barettin and derivatives thereof for the cosmetic treatment of skin aging. Yet another aspect is the use of the compound of formula (I) or any pharmaceutically acceptable salt thereof in a solution for the preservation and/or washing of organs. A final aspect of the present invention is the use of barettin and derivatives thereof as a food and/or feed additive.

  本发明涉及本文中的式(I)化合物，其中包括巴雷汀及其衍生物，或其任何药学上可接受的盐，用作药物。此外，本发明还涉及同样的化合物用于治疗与氧化应激相关的疾病和治疗炎症性疾病。本发明的另一个方面是利用巴雷汀及其衍生物进行皮肤衰老的化妆治疗。还有另一个方面是将式(I)化合物或其任何药学上可接受的盐溶液用于器官的保存和/或清洗。本发明的最后一个方面是将巴雷汀及其衍生物用作食品和/或饲料添加剂。
• BARETTIN AND DERIVATIVES THEREOF FOR MEDICAL USE, IN PARTICULAR FOR THE TREATMENT OF DISEASES RELATED TO OXIDATIVE STRESS OR INFLAMMATION, AND FOR PRESERVING OR WASHING ORGANS
  申请人：ABC Bioscience AS

  公开号：US20160039796A1

  公开（公告）日：2016-02-11

  The compounds of formula (I) herein include barettin and derivatives thereof, or any pharmaceutically acceptable salt thereof for use as a medicament. Further the compounds may be used for the treatment of diseases related to oxidative stress and the treatment of inflammatory diseases; for the cosmetic treatment of skin aging; in a solution for the preservation and/or washing of organs; and as a food and/or feed additive.

  公式（I）的化合物包括barettin及其衍生物，或任何医药上可接受的盐，用作药物。此外，这些化合物可用于治疗与氧化应激相关的疾病和炎症性疾病的治疗；用于皮肤老化的美容治疗；在溶液中用于器官的保存和/或清洗；以及作为食品和/或饲料添加剂。