1-Benzyloxy-3-chloro-5-methoxy-benzene | 236112-47-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-Benzyloxy-3-chloro-5-methoxy-benzene
• 英文别名: 1-(Benzyloxy)-3-chloro-5-methoxybenzene；1-chloro-3-methoxy-5-phenylmethoxybenzene
• CAS: 236112-47-3
• 化学式: C₁₄H₁₃ClO₂
• 分子量: 248.709
• InChiKey: MBDBTQICOPIPIJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-氯-5-甲氧基苯酚 、 苯甲醇 在 二苯基-2-吡啶膦 、 偶氮二甲酸二叔丁酯 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 以69%的产率得到1-Benzyloxy-3-chloro-5-methoxy-benzene
  参考文献：
  名称：

  Diphenyl 2-pyridylphosphine and di-tert-butylazodicarboxylate:Convenient reagents for the Mitsunobu reaction

  摘要：

  New reagents that resolve the problem of separating products from the numerous byproducts in the Mitsunobu reaction have been introduced. Substitution of a basic triarylphosphine and an acid labile azodicarboxylate for triphenylphosphine and diethy azodicarboxylate provide an improved procedure allowing for facile isolation of desired products in good yields and excellent purity. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00819-9

文献信息

• Heterocyclic Kinase Inhibitors
  申请人：Hasvold A. Lisa

  公开号：US20070254867A1

  公开（公告）日：2007-11-01

  Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

  具有公式的化合物对于抑制蛋白激酶很有用。还公开了制备这些化合物的方法、含有这些化合物的组合物和使用这些化合物的治疗方法。
• US7456169B2
  申请人：——

  公开号：US7456169B2

  公开（公告）日：2008-11-25
• Diphenyl 2-pyridylphosphine and di-tert-butylazodicarboxylate:Convenient reagents for the Mitsunobu reaction
  作者：Mehrak Kiankarimi、Richard Lowe、James R. McCarthy、Jeffrey P. Whitten

  DOI：10.1016/s0040-4039(99)00819-9

  日期：1999.6

  New reagents that resolve the problem of separating products from the numerous byproducts in the Mitsunobu reaction have been introduced. Substitution of a basic triarylphosphine and an acid labile azodicarboxylate for triphenylphosphine and diethy azodicarboxylate provide an improved procedure allowing for facile isolation of desired products in good yields and excellent purity. (C) 1999 Elsevier Science Ltd. All rights reserved.