1H-Indole-3-ethanimidic acid, 1-methyl-, 1-methylethyl ester | 153777-78-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1H-Indole-3-ethanimidic acid, 1-methyl-, 1-methylethyl ester
• 英文别名: propan-2-yl 2-(1-methylindol-3-yl)ethanimidate
• CAS: 153777-78-7
• 化学式: C₁₄H₁₈N₂O
• 分子量: 230.31
• InChiKey: AFBZBZFIGOHAKT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  38
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP0915872B1

  公开（公告）日：2003-05-14
• SUBSTITUTED BISINDOLYLMALEIMIDES
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP1242409A2

  公开（公告）日：2002-09-25
• DEUTERIUM-ENRICHED ENZASTAURIN
  申请人：Czarnik Anthony W.

  公开号：US20090069377A1

  公开（公告）日：2009-03-12

  The present application describes deuterium-enriched enzastaurin, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.
• [EN] SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION<br/>[FR] BISINDOLYLMALEIMIDES SUBSTITUES D'INHIBITION DE LA PROLIFERATION CELLULAIRE
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：WO1998004552A1

  公开（公告）日：1998-02-05

  (EN) Compounds of formula (I) wherein R1 and R1' are independently alkyl, aryl, alkenyl or alkynyl; R2 and R2' are independently hydrogen or alkyl; R4, R5, R6 and R7 each independently are (a), CO2R9, CH2OR10, CHO, CH2NR11R12, CON(R13)2, hydrogen, halogen, cyano, alkyl, hydroxy, alkoxy, aryloxy, haloalkyl, nitro, amino, acylamino, aralkyloxy, monoalkylamino, dialkylamino, alkylthio, alkylsulphinyl or alkylsulphonyl, provided that at least one of R4, R5, R6 or R7 is cyano, (a), CO2R9, CH2OR10, CH2NR11R12, CHO or CON(R13)2; R8 is alkyl, aralkyl or aryl; R9 is alkyl, aralkyl or aryl; R10 is hydrogen, alkyl, aralkyl or aryl; R11 and R12 are independently hydrogen, alkyl, aryl, aralkyl or acyl; R13 is hydrogen, alkyl, aryl or aralkyl; and one of X and Y signifies O and the other signifies O, S, (H,OH) or (H,H); as well as pharmaceutically acceptable prodrugs or salts of acidic compounds of formula (I) with bases and or basic compounds of formula (I) with acids are antiproliferative agents useful in the treatment of cancer.(FR) Composés de la formule (I) dans laquelle R1 et R1' représentent indépendamment l'un de l'autre alkyle, aryle, alcényle ou alcynile; R2 and R2' représentent indépendamment l'un de l'autre hydrogène ou alkyl; R4, R5, R6 et R7 représentent indépendamment les uns des autres (a), CO2R9, CH2OR10, CHO, CH2NR11R12, CON(R13)2, hydrogène, halogène, cyano, alkyle, hydroxy, alcoxy, ariloxy, haloalkyle, nitro, amino, acylamino, aralkyloxy, monoalkylamino, dialkylamino, alkylthio, alkylsulfinyl or alkylsulfonyle, si l'un des radicaux R4, R5, R6 ou R7 représente cyano (a), CO2R9, CH2OR10, CH2NR11R12, CHO ou CON(R13)2; R8 représente alkyle, aralkyle ou aryle; R9 représente alkyle, aralkyle ou aryle; R10 représente hydrogène, alkyle, aralkyle ou aryle; R11 et R12 représentent indépendamment l'un de l'autre hydrogène, alkyle, aryle, aralkyle ou acyle; R13 représente hydrogène, alkyle, aryle ou aralkyle; et l'un des éléments X et Y signifie O et l'autre signifie O, S, (H,OH) ou (H,H); de même que des sels ou des promédicaments pharmacologiquement acceptables de composés acidifiants de la formule (I), avec des bases et/ou des composés basiques de ladite formule (I) qui constituent des agents antiproliférants utilisables dans le traitement du cancer.
• [EN] SUBSTITUTED PYRROLES<br/>[FR] PYRROLES SUBSTITUES
  申请人：HOFFMANN LA ROCHE

  公开号：WO2001046178A2

  公开（公告）日：2001-06-28

  Disclosed are substituted pyrroles having formula (I), wherein R?1, R2, R1' and R2'¿ are as defined in the claims and in the description. These compounds and their pharmaceutically acceptable salts are useful in the treatment and/or control of cell proliferative disorders, in particular cancer. Also disclosed are pharmaceutical compositions containing the foregoing compounds.