3-(苄氧基)二氢呋喃-2,5-二酮 | 75322-91-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3-(苄氧基)二氢呋喃-2,5-二酮
• 英文名称: 3-Benzyloxy-dihydro-furan-2,5-dione
• 英文别名: 3-Phenylmethoxyoxolane-2,5-dione
• CAS: 75322-91-7
• 化学式: C₁₁H₁₀O₄
• 分子量: 206.198
• InChiKey: JRVMENAPLKSAPU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-(苄氧基)二氢呋喃-2,5-二酮 在 dimethyl sulfide borane 作用下， 生成 α-benzyloxy-γ-butyrolactone 、 4-(benzyloxy)dihydrofuran-2(3H)-one
  参考文献：
  名称：

  脂肪酶催化的α-取代环酸酐的高度区域选择性开环

  摘要：

  脂肪酶Amano P不可逆地优先在受阻较小的羰基上催化α-取代的环状酸酐1的开环，从而得到具有高区域选择性的单酯。

  DOI：

  10.1016/s0040-4039(00)99517-0
• 作为产物：
  描述：

  benzoxysuccinic acid 、 乙酰氯 以48%的产率得到
  参考文献：
  名称：

  HALLSTROEM G.; ANDERSON E.; LINDEKE B., ACTA PHARM. SUEC., 1980, 17, NO 1, 31-54

  摘要：

  DOI：

文献信息

• Polymers with structure-defined functions
  申请人：Greener Bryan

  公开号：US20050032929A1

  公开（公告）日：2005-02-10

  An alternating copolymer comprising a backbone of residues of a maleic anhydride derivative and those of a compound containing vinylic unsaturation, which also comprises residues of an active compound containing a nucleophilic group, bound to the backbone by a residue of the nucleophilic group, including such copolymer comprising residues of an active compound containing alcohol, thiol or amine group. The chemical and biological propertieis of actives, such as protease inhibitors, neurotransmitter drugs, and other small molecule active drugs, are enhanced, and new applications enabled. Also, artefacts, including a solid medical implant device, dressing or scaffold or a fluid adhesive or medicinal composition comprising such a polymer, and a method of use of such polymer, including a method for the treatment or prophylaxis of wounds

  一种交替共聚物，其骨架由马来酸酐衍生物残基和含有乙烯基不饱和度的化合物残基组成，其中还包括含有亲核基的活性化合物残基，通过亲核基残基与骨架结合，包括含有醇、硫醇或胺基的活性化合物残基的此类共聚物。活性物质（如蛋白酶抑制剂、神经递质药物和其他小分子活性药物）的化学和生物特性得到了增强，并实现了新的应用。此外，还包括固体医疗植入装置、敷料或支架，或包含此类聚合物的流体粘合剂或药物组合物，以及此类聚合物的使用方法，包括治疗或预防伤口的方法。
• HIRATAKE, JUN;YAMAMOTO, KAZUYOSHI;YAMAMOTO, YUKIO;ODA, JUNICHI, TETRAHEDRON LETT., 30,(1989) N2, C. 1555-1556
  作者：HIRATAKE, JUN、YAMAMOTO, KAZUYOSHI、YAMAMOTO, YUKIO、ODA, JUNICHI

  DOI：——

  日期：——
• POLYMERS WITH STRUCTURE-DEFINED FUNCTIONS
  申请人：Smith & Nephew PLC

  公开号：EP1436334A1

  公开（公告）日：2004-07-14
• Polymers With Structure-Defined Functions
  申请人：GREENER Bryan

  公开号：US20110300096A1

  公开（公告）日：2011-12-08

  An alternating copolymer comprising a backbone of residues of a maleic anhydride derivative and those of a compound containing vinylic unsaturation, which also comprises residues of an active compound containing a nucleophilic group, bound to the backbone by a residue of the nucleophilic group, including such a copolymer comprising residues of an active compound containing an alcohol, thiol or amine group. The chemical and biological properties of actives, such as protease inhibitors, neurotransmitter drugs, and other small molecule active drugs, are enhanced, and new applications enabled. Also, artefacts, including a solid medical implant device, dressing or scaffold or a fluid adhesive or medicinal composition comprising such a polymer, and a method of use of such a polymer, including a method for the treatment or prophylaxis of wounds.
• US4470877A
  申请人：——

  公开号：US4470877A

  公开（公告）日：1984-09-11