3-(苯基)-2-氧代丙酸乙酯 | 6362-56-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3-(苯基)-2-氧代丙酸乙酯
• 英文名称: ethyl 3-phenylpyruvate
• 英文别名: ethyl phenylpyruvate；ethyl 3-(phenyl)-2-oxopropanoate；α-hydroxy-cinnamic acid ethyl ester；α-Hydroxy-zimtsaeure-aethylester；Ethyl hydroxycinnamate；ethyl 2-hydroxy-3-phenylprop-2-enoate
• CAS: 6362-56-7
• 化学式: C₁₁H₁₂O₃
• 分子量: 192.214
• InChiKey: KURIMYUGSIYKLW-UHFFFAOYSA-N

物化性质

• 沸点：
  331.5±42.0 °C(Predicted)
• 密度：
  1.170±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(苯基)-2-氧代丙酸乙酯 在 fluorine 作用下， 以 1,1,2-三氯三氟乙烷（CFC-113） 、 乙腈 为溶剂， 反应 2.5h， 以40%的产率得到ethyl 3-phenyl-3-fluoropyruvate
  参考文献：
  名称：

  .alpha.-Fluorination of ketones. 1. Direct fluorination of pyruvic acid derivatives by using molecular fluorine

  摘要：

  DOI：

  10.1021/jo00345a042
• 作为产物：
  描述：

  3-氰基-3-苯基丙酮酸乙酯 在 乙醇 、 硫酸 作用下， 生成 3-(苯基)-2-氧代丙酸乙酯
  参考文献：
  名称：

  Distribution and status of lynx in the border region between Czech Republic, Germany and Austria

  摘要：

  This paper summarizes available information concerning the presence of the Eurasian lynx Lynx lynx Linneaus, 1758 in the Sumava Mountains and adjacent areas along the common border of Czech Republic, Germany and Austria. Our data give an overview of the lynx population occupying the border region between the three countries from 1990 to 1999. We estimated population size using radiotracking data. From 1990 to 1998, population increased from under 20 to nearly 70 resident animals. During this time, reproduction increased as well, with a maximum of 55 kittens observed in the rearing period of 1998 to 1999. Mortality data indicated that illegal hunting was widespread. Our paper discusses possible links with other lynx populations and describes the legal status of lynx in the three different countries. Current management approaches are outlined and steps toward a long-term conservation plan for the population are proposed.

  DOI：

  10.1007/bf03192427

文献信息

• Synthesis of Butenolides via a Horner–Wadsworth–Emmons Cascading Dimerization Reaction
  作者：Jack Everson、Milton J. Kiefel

  DOI：10.1021/acs.joc.9b02015

  日期：2019.12.6

  structurally related butenolides has been observed while we were exploring the substrate-scope of a Horner-Wadsworth-Emmons (HWE) reaction. While aliphatic aldehydes gave the expected HWE product, aromatic aldehydes furnished butenolides, resulting from the dimerization of the HWE product during desilylation of the initially formed HWE adduct. In addition to isolating butenolides in a high yield, we

  在我们研究霍纳-沃兹沃思-埃蒙斯（HWE）反应的底物范围时，已观察到一系列结构相关的丁烯内酯的有效合成。尽管脂族醛提供了预期的HWE产物，但芳族醛提供了丁烯内酯，这是由于在最初形成的HWE加合物的甲硅烷基化过程中HWE产物的二聚作用所致。除了高产率地分离丁烯内酯外，我们还精确地确定了二聚化发生的时间。
• Induction of apoptosis in cancer cells
  申请人：——

  公开号：US20030176506A1

  公开（公告）日：2003-09-18

  The present invention provides compounds that are inducers or inhibitors of apoptosis or apoptosis preceded by cell-cycle arrest. In addition, the present invention provides pharmaceutical compositions and methods for treating mammals with leukemia or other forms of cancer or for treating disease conditions caused by apoptosis of cells.

  本发明提供诱导或抑制细胞凋亡或细胞周期阻滞后的细胞凋亡的化合物。此外，本发明提供制备药物组合物和方法，用于治疗哺乳动物的白血病或其他形式的癌症，或用于治疗由细胞凋亡引起的疾病情况。
• Photopolymerizable oxetane derivative and liquid-crystal composition containing it
  申请人：Syundo Ryushi

  公开号：US20050224757A1

  公开（公告）日：2005-10-13

  Provided are a liquid-crystal compound and a liquid-crystal composition containing the compound, of which the advantages are that they show nematic hybrid orientation on a rubbed TAC substrate, they are polymerizable in open air and they readily give a polymer having a high degree of polymerization even when exposed to a relatively small total quantity of light. The films formed by photopolymerizing them keep nematic hybrid orientation. The compound is represented by formula (1): wherein R 1 is a hydrogen or an alkyl; R 2 is a hydrogen, —OCF 3 , etc.; A 1 is a 1,4-phenylene, etc.; A 2 and A 3 are independently a 1,4-cyclohexylene, a 1,4-phenylene, etc.; X 1 is a single bond, —O—, etc.; X 2 and X 3 are independently a single bond, —COO—, —C≡C—, —CONH—, etc.; m is an integer of from 0 to 20; and n is 1 or 0.

  提供了一种液晶化合物和含有该化合物的液晶组合物，其优点是在擦过的TAC基板上显示向列杂化取向，可以在空气中聚合，并且即使暴露于相对较小的光总量下也很容易产生高度聚合的聚合物。用光聚合它们形成的薄膜保持向列杂化取向。该化合物由式（1）表示：其中R1是氢或烷基；R2是氢，—OCF3等；A1是1,4-苯撑等；A2和A3分别是1,4-环己撑，1,4-苯撑等；X1是单键，—O—等；X2和X3分别是单键，—COO—，—C≡C—，—CONH—等；m是0到20的整数；n是1或0。
• Gault; Weick, Bulletin de la Societe Chimique de France, 1922, vol. <4> 31, p. 887
  作者：Gault、Weick

  DOI：——

  日期：——
• Gault; Weick, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1920, vol. 171, p. 396
  作者：Gault、Weick

  DOI：——

  日期：——