N-(2-(5-hydroxy-1H-indol-3-yl)ethyl)palmitamide | 212707-51-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: N-(2-(5-hydroxy-1H-indol-3-yl)ethyl)palmitamide
• 英文别名: N-palmitoylserotonin；N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]hexadecanamide
• CAS: 212707-51-2
• 化学式: C₂₆H₄₂N₂O₂
• 分子量: 414.632
• InChiKey: AKQOZSXOPVLUHA-UHFFFAOYSA-N

物化性质

• 溶解度：
  乙醇中≤30mg/ml；DMSO中15mg/ml；二甲基甲酰胺中30mg/ml

计算性质

• 辛醇/水分配系数(LogP)：
  7.8
• 重原子数：
  30
• 可旋转键数：
  17
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  65.1
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  Hexadecanoic acid [2-(1-hydroxy-1H-indol-3-yl)-ethyl]-amide 在 甲酸 作用下， 以22%的产率得到Hexadecanoic acid [2-(1-formyl-5-hydroxy-1H-indol-3-yl)-ethyl]-amide
  参考文献：
  名称：

  Syntheses of 1-Hydroxytryptamines and Serotonins Having Fattyacyl or (E)-3-Phenylpropenoyl Derivatives as an Nb-Substituent, and a Novel Homologation on the 3-Substituent of the 1-Hydroxytryptamines upon Treatment with Diazomethane

  摘要：

  1-Hydroxytryptamines (6a-f) having (E)-3-phenyl-, (E)-3-(4-hydroxypheny)-, (E)-3-(4-hydroxy-3-methoxyphenyl)propenoyl, octanoyl, hexadecanoyl, and docosanoyl group as a Nb-substituent are prepared for the first time. Preparations of serotonins (2a- c, e) from the corresponding 1-hydroxytryptamines (6a- c, e) are also reported. A novel homologation on the 3-substituent of 1-hydroxytryptamines is discovered upon treatment with diazomethane in chloroform or dichloromethane.

  DOI：

  10.3987/com-98-8156

文献信息

• Compounds, Compositions and Methods for Making the Same
  申请人：Vafai Scott

  公开号：US20090264496A1

  公开（公告）日：2009-10-22

  The present invention provides compounds and/or compositions that modulate PP2A methylation and/or activity and methods for preparing the same, which are useful for modulating the demethylation of PP2A, modulating the methylation of PP2A and/or modulating the activity of PP2A.

  本发明提供了能够调节PP2A甲基化和/或活性的化合物和/或组合物，以及制备这些化合物和/或组合物的方法。这些化合物和/或组合物可用于调节PP2A的去甲基化、甲基化和/或活性。
• Identification of an arylalkylamine<i>N</i>-acyltransferase from<i>Drosophila melanogaster</i>that catalyzes the formation of long-chain<i>N</i>-acylserotonins
  作者：Daniel R. Dempsey、Kristen A. Jeffries、Ryan L. Anderson、Anne-Marie Carpenter、Santiago Rodriquez Opsina、David J. Merkler

  DOI：10.1016/j.febslet.2013.12.027

  日期：2014.2.14

  Arylalkylamine N‐acyltransferase‐like 2 2 (AANATL2) from Drosophila melanogaster was expressed and shown to catalyze the formation of long‐chain N‐acylserotonins and N‐acydopamines. Subsequent identification of endogenous amounts of N‐acylserotonins and colocalization of these fatty acid amides and AANATL2 transcripts gives supporting evidence that AANATL2 has a role in the biosynthetic formation of these important cell signalling lipids.
• COMPOUNDS, COMPOSITIONS AND METHODS FOR MAKING THE SAME
  申请人：Signum Biosciences, Inc.

  公开号：US20170266161A1

  公开（公告）日：2017-09-21

  The present invention provides compounds and/or compositions that modulate PP2A methylation and/or activity and methods for preparing the same, which are useful for modulating the demethylation of PP2A, modulating the methylation of PP2A and/or modulating the activity of PP2A.
• HUMAN GUT MICROBIOME-DERIVED BIOSYNTHETIC ENZYMES FOR PRODUCTION OF FATTY ACID AMIDES
  申请人：Massachusetts Institute of Technology

  公开号：US20200299738A1

  公开（公告）日：2020-09-24

  Disclosed herein, in some embodiments, are vectors encoding biosynthetic enzymes from gut microbiome-derived bacterium (e.g., Clostridia enzymes), engineered cells comprising the vectors, and methods of using biosynthetic enzymes from gut microbiome-derived bacterium (e.g., Clostridia enzymes) to produce fatty acid amides.
• US9486441B2
  申请人：——

  公开号：US9486441B2

  公开（公告）日：2016-11-08