1-Arachidonoyl-3-arachidonoyl-sn-glycerol | 95034-09-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 1-Arachidonoyl-3-arachidonoyl-sn-glycerol
• 英文别名: [2-hydroxy-3-[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyl]oxypropyl] (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
• CAS: 95034-09-6
• 化学式: C₄₃H₆₈O₅
• 分子量: 665.0
• InChiKey: BVPIMSGTEQDXIH-XCHUKFSYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.4
• 重原子数：
  48
• 可旋转键数：
  34
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Fluorescence-Labelled Fatty Acids and Uses Thereof
  申请人：SANOFI

  公开号：US20150285812A1

  公开（公告）日：2015-10-08

  The present invention relates to a composition comprising (i) a fluorescent-labelled fatty acid and (ii) a fatty acid binding compound, wherein (a) the fatty acid component of the fluorescent-labelled fatty acid binds the fatty acid binding compound and (b) the fluorescent component of the fluorescent-labelled fatty acid and the fatty acid binding compound interact to elicit FRET (Förster resonance energy transfer) effects. Moreover, the invention is directed to a method for identifying and/or characterizing a compound of interest by contacting a fluorescent-labelled fatty acid with a fatty acid binding compound under conditions that allow for binding and for FRET (Förster resonance energy transfer) effects, and then contacting the fluorescent-labelled fatty acid bound to the fatty acid binding compound with a compound of interest and determining the change in fluorescence. In addition, the invention pertains to corresponding kits of parts and uses of the compositions and methods.

  本发明涉及一种组合物，包括（i）一种荧光标记的脂肪酸和（ii）一种脂肪酸结合化合物，其中（a）荧光标记的脂肪酸的脂肪酸成分结合脂肪酸结合化合物，（b）荧光标记的脂肪酸的荧光成分和脂肪酸结合化合物相互作用，以引发FRET（Förster共振能量转移）效应。此外，本发明还涉及一种方法，通过在允许结合和FRET（Förster共振能量转移）效应的条件下，将荧光标记的脂肪酸与脂肪酸结合化合物接触，然后将荧光标记的脂肪酸与感兴趣的化合物结合，并测定荧光的变化来识别和/或表征感兴趣的化合物。此外，本发明还涉及相应的部件套件和组合物和方法的用途。
• [EN] FLUORESCENCE-LABELLED FATTY ACIDS AND USES THEREOF<br/>[FR] ACIDES GRAS MARQUÉS PAR FLUORESCENCE ET LEURS UTILISATIONS
  申请人：SANOFI SA

  公开号：WO2014037394A1

  公开（公告）日：2014-03-13

  The present invention relates to a composition comprising (i) a fluorescent-labelled fatty acid and (ii) a fatty acid binding compound, wherein (a) the fatty acid component of the fluorescent- labelled fatty acid binds the fatty acid binding compound and (b) the fluorescent component of the fluorescent-labelled fatty acid and the fatty acid binding compound interact to elicit FRET (Förster resonance energy transfer) effects. Moreover, the invention is directed to a method for identifying and/or characterizing a compound of interest by contacting a fluorescent-labelled fatty acid with a fatty acid binding compound under conditions that allow for binding and for FRET (Förster resonance energy transfer) effects, and then contacting the fluorescent-labelled fatty acid bound to the fatty acid binding compound with a compound of interest and determining the change in fluorescence. In addition, the invention pertains to corresponding kits of parts and uses of the compositions and methods.