5,7-Diazido-3-phenyl-[1,3]thiazolo[4,5-d]pyrimidine-2-thione | 189895-63-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5,7-Diazido-3-phenyl-[1,3]thiazolo[4,5-d]pyrimidine-2-thione
• CAS: 189895-63-4
• 化学式: C₁₁H₅N₉S₂
• 分子量: 327.353
• InChiKey: XOWITSFYQXEZAN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  115
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  5,7-Diazido-3-phenyl-[1,3]thiazolo[4,5-d]pyrimidine-2-thione 在 sodium dithionite 作用下， 以 乙醇 、 水 为溶剂， 反应 1.0h， 以61%的产率得到5,7-Diamino-3-phenyl-[1,3]thiazolo[4,5-d]pyrimidine-2-thione
  参考文献：
  名称：

  Condensed thiazoles, I: Synthesis of 5,7-disubstituted thiazolo[4,5-d]pyrimidines as possible anti-HIV, anticancer, and antimicrobial agents

  摘要：

  A convenient and simple synthesis of 5-mercapto-3-phenyl-2-thioxo-2,3-dihydrothiazolo-[4,5-d]pyrimidin-7(6H)-one (2) and its 5,7-dichloro (3), 5,7-diazido (4), 5,7-diamino (5), 5,7-dimerapto (6), 5,7-dimethylthio (7), and 6-methyl-5-methylthio (8) derivatives is described. The prepared compounds were screened for their in vitro anti-HIV, anticancer, antibacterial, and antifungal activities.

  DOI：

  10.1007/bf00844696
• 作为产物：
  描述：

  3-Phenyl-2,5-dithioxo-2,3,5,6-tetrahydrothiazolo[4,5-d]pyrimidin-7(4H)-one 在 sodium azide 、 五氯化磷 作用下， 以 丙酮 、 三氯氧磷 为溶剂， 反应 7.0h， 生成 5,7-Diazido-3-phenyl-[1,3]thiazolo[4,5-d]pyrimidine-2-thione
  参考文献：
  名称：

  Condensed thiazoles, I: Synthesis of 5,7-disubstituted thiazolo[4,5-d]pyrimidines as possible anti-HIV, anticancer, and antimicrobial agents

  摘要：

  A convenient and simple synthesis of 5-mercapto-3-phenyl-2-thioxo-2,3-dihydrothiazolo-[4,5-d]pyrimidin-7(6H)-one (2) and its 5,7-dichloro (3), 5,7-diazido (4), 5,7-diamino (5), 5,7-dimerapto (6), 5,7-dimethylthio (7), and 6-methyl-5-methylthio (8) derivatives is described. The prepared compounds were screened for their in vitro anti-HIV, anticancer, antibacterial, and antifungal activities.

  DOI：

  10.1007/bf00844696

文献信息

• Condensed thiazoles, I: Synthesis of 5,7-disubstituted thiazolo[4,5-d]pyrimidines as possible anti-HIV, anticancer, and antimicrobial agents
  作者：N. S. Habib、S. M. Rida、E. A. M. Badawey、H. T. Y. Fahmy

  DOI：10.1007/bf00844696

  日期：1996.11

  A convenient and simple synthesis of 5-mercapto-3-phenyl-2-thioxo-2,3-dihydrothiazolo-[4,5-d]pyrimidin-7(6H)-one (2) and its 5,7-dichloro (3), 5,7-diazido (4), 5,7-diamino (5), 5,7-dimerapto (6), 5,7-dimethylthio (7), and 6-methyl-5-methylthio (8) derivatives is described. The prepared compounds were screened for their in vitro anti-HIV, anticancer, antibacterial, and antifungal activities.