((3R,4R,5R)-3,4-Dihydroxy-5-propyl-piperidin-1-yl)-acetic acid | 277298-34-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: ((3R,4R,5R)-3,4-Dihydroxy-5-propyl-piperidin-1-yl)-acetic acid
• 英文别名: 1-Piperidineaceticacid, 3,4-dihydroxy-5-propyl-, (3R,4R,5R)-；2-[(3R,4R,5R)-3,4-dihydroxy-5-propylpiperidin-1-yl]acetic acid
• CAS: 277298-34-7
• 化学式: C₁₀H₁₉NO₄
• 分子量: 217.265
• InChiKey: RRZRFLJAGRLBRS-NQMVMOMDSA-N

物化性质

• 沸点：
  400.7±24.0 °C(Predicted)
• 密度：
  1.222±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.2
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  81
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  ((3R,4R,5R)-3,4-Dihydroxy-5-propyl-piperidin-1-yl)-acetic acid benzyl ester 在 palladium on activated charcoal 氢气 作用下， 以 乙酸乙酯 为溶剂， 生成 ((3R,4R,5R)-3,4-Dihydroxy-5-propyl-piperidin-1-yl)-acetic acid
  参考文献：
  名称：

  A new asymmetric route to substituted piperidines: synthesis of N-alkyl-3,4-dihydroxy-5-alkylpiperidines

  摘要：

  A facile asymmetric synthesis of N-alkyl-3,4-dihydroxy-5-alkylpiperidines has been developed, which is based on an asymmetric alkylation reaction of the SAMP hydrazone of N-BOC piperidinone. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)00267-7

文献信息

• A new asymmetric route to substituted piperidines: synthesis of N-alkyl-3,4-dihydroxy-5-alkylpiperidines
  作者：Hongbin Sun、Kim M Millar、Jingsong Yang、Khalil Abboud、Benjamin A Horenstein

  DOI：10.1016/s0040-4039(00)00267-7

  日期：2000.4

  A facile asymmetric synthesis of N-alkyl-3,4-dihydroxy-5-alkylpiperidines has been developed, which is based on an asymmetric alkylation reaction of the SAMP hydrazone of N-BOC piperidinone. (C) 2000 Elsevier Science Ltd. All rights reserved.