Unii-G3MY6fge1J | 701232-94-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: Unii-G3MY6fge1J
• 英文别名: 2-[6-[4-amino-7,7-dimethyl-2-(trifluoromethyl)pyrimido[4,5-b][1,4]oxazin-6-yl]spiro[1,2-dihydroindene-3,4'-cyclohexane]-1'-yl]acetic acid
• CAS: 701232-94-2
• 化学式: C₂₅H₂₇F₃N₄O₃
• 分子量: 488.5
• InChiKey: YFJNLPDVCDNOMJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  35
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  111
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• Anorectic
  申请人：Ogawa Nobuya

  公开号：US20070027093A1

  公开（公告）日：2007-02-01

  The present invention relates to an anorectic containing a compound having a DGAT inhibitory activity (DGAT1 inhibitory activity) or a prodrug thereof or a pharmaceutically acceptable salt thereof as an active ingredient. The present invention provides an anti-obesity drug which is an anorectic that does not directly act on the central nervous system and is satisfactory in terms of activity, and a therapeutic strategy for preventing or treating obesity.

  本发明涉及一种含有具有DGAT抑制活性（DGAT1抑制活性）的化合物或其前药或其药学上可接受的盐作为活性成分的厌食剂。本发明提供了一种抗肥胖药物，它是一种不直接作用于中枢神经系统且在活性方面令人满意的厌食剂，以及预防或治疗肥胖的治疗策略。
• Fused Bicyclic Nitrogen-Containing Heterocycles
  申请人：Fox M. Brian

  公开号：US20070244096A1

  公开（公告）日：2007-10-18

  Compounds, pharmaceutical compositions and methods that are useful in the treatment or prevention of metabolic and cell proliferative diseases or conditions are provided herein. In particular, the invention provides compounds which modulate the activity of proteins involved in lipid metabolism and cell proliferation.
• US7244727B2
  申请人：——

  公开号：US7244727B2

  公开（公告）日：2007-07-17