3-Methyl-3H-indol-3-ol | 216101-54-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-Methyl-3H-indol-3-ol
• 英文别名: 3-methylindol-3-ol
• CAS: 216101-54-1
• 化学式: C₉H₉NO
• 分子量: 147.17
• InChiKey: HYZSAMREMMAXPO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  32.6
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Novel enzymes and metabolites involved in skatole metabolism
  申请人：University of Guelph

  公开号：US20020197663A1

  公开（公告）日：2002-12-26

  Novel metabolites and enzymes involved in skatole metabolism are disclosed. The novel metabolites are 3-OH-3-methylindolenine (HMI); 3-methyloxindole (3MOI); indole-3-carbinol (I-3C); and 2-aminoacetophenone (2-AM). Measuring levels of these metabolites in a pig may be useful in identifying the pig's ability to metabolize skatole and its susceptibility to boar taint. The novel enzymes involved in skatole metabolism are aldehyde oxidase and CYP2A6. Enhancing the activity of these enzymes may be useful in enhancing skatole metabolism and reducing boar taint. The identification of the enzyme also allows the development of screening assays for substances that interact with these enzymes and skatole metabolism. Pigs having high levels of these enzymes may be selected and bred to produce pigs that have a lower incidence of boar taint.

  本发明揭示了参与indole代谢的新代谢产物和酶。新代谢产物包括3-OH-3-methylindolenine（HMI）；3-methyloxindole（3MOI）；indole-3-carbinol（I-3C）和2-aminoacetophenone（2-AM）。测量猪体内这些代谢产物的水平可能有助于确定猪体内代谢indole的能力以及其对睾丸气味的敏感性。参与indole代谢的新酶包括醛氧化酶和CYP2A6。增强这些酶的活性可能有助于增强indole代谢并减少睾丸气味。酶的鉴定还允许开发筛选与这些酶和indole代谢相互作用的物质的筛选试验。选择具有高水平这些酶的猪进行繁殖，可以生产出具有较低睾丸气味发生率的猪。
• Method of detecting and reducing boar taint
  申请人：——

  公开号：US20040033552A1

  公开（公告）日：2004-02-19

  A method of preventing or reducing boar taint is described. The method involves increasing the metabolism of skatole in a pig by modulating the activity or expression of the enzymes involved in skatole metabolism.

  本发明描述了一种预防或减少公猪异味的方法。该方法涉及通过调节参与吲哚醇代谢的酶的活性或表达来增加猪体内吲哚醇的代谢率。
• Genetic markers for skatole metabolism
  申请人：Squires James E.

  公开号：US20070031837A1

  公开（公告）日：2007-02-08

  Novel metabolites and enzymes involved in skatole metabolism are disclosed. The novel metabolites are 3-OH-3-methylindolenine (HMI); 3-methyloxindole (3MOI); indole-3-carbinol (I-3C); and 2-aminoacetophenone (2-AM). Measuring levels of these metabolites in a pig may be useful in identifying the pig's ability to metabolize skatole and its susceptibility to boar taint. The novel enzymes involved in skatole metabolism are aldehyde oxidase and CYP2A6. Enhancing the activity of these enzymes may be useful in enhancing skatole metabolism and reducing boar taint. The identification of the enzyme also allows the development of screening assays for substances that interact with these enzymes and skatole metabolism or for genetic screening to identify pigs on the basis of their skatole metabolism. Pigs having high levels of these enzymes may be selected and bred to produce pigs that have a lower incidence of boar taint.

  本发明披露了参与猪笨味代谢的新代谢产物和酶。这些新代谢产物是3-OH-3-甲基吲哚啉（HMI）；3-甲氧基吲哚（3MOI）；吲哚-3-甲醇（I-3C）；和2-氨基苯乙酮（2-AM）。测量猪体内这些代谢产物的水平可能有助于确定猪对笨味的代谢能力以及其易感性。参与笨味代谢的新酶是醛氧化酶和CYP2A6。增强这些酶的活性可能有助于增强笨味代谢并减少猪笨味。酶的鉴定还允许开发筛选与这些酶和笨味代谢相互作用的物质或进行基因筛选以确定猪的笨味代谢能力的检测方法。具有高水平这些酶的猪可以被选择和繁殖，以生产出更少发生猪笨味的猪。
• NOVEL ENZYMES AND METABOLITES INVOLVED IN SKATOLE METABOLISM
  申请人：University of Guelph

  公开号：EP1218534A2

  公开（公告）日：2002-07-03
• GENETIC MARKERS FOR SKATOLE METABOLISM
  申请人：UNIVERSITY OF GUELPH

  公开号：EP1623004A2

  公开（公告）日：2006-02-08