4-Oxa-1-aza-bicyclo[3.3.1]nonan-6-one oxime; hydrochloride | 107903-99-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 4-Oxa-1-aza-bicyclo[3.3.1]nonan-6-one oxime; hydrochloride
• 英文别名: N-(4-oxa-1-azabicyclo[3.3.1]nonan-6-ylidene)hydroxylamine;hydrochloride
• CAS: 107903-99-1
• 化学式: C₇H₁₂N₂O₂*ClH
• 分子量: 192.645
• InChiKey: SPDVMKVDHLCEMG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.34
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  45.1
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-Oxa-1-aza-bicyclo[3.3.1]nonan-6-one oxime; hydrochloride 在 sodium hydroxide 、 lithium aluminium tetrahydride 作用下， 生成 4-Amino-5-chloro-2-methoxy-N-(4-oxa-1-aza-bicyclo[3.3.1]non-6-yl)-benzamide
  参考文献：
  名称：

  The synthesis of 2-morpholine carboxylic acid derivatives and their elaboration to 1-aza-4-oxabicyclo[3.3.1]nonan-6-one.

  摘要：

  Two syntheses of novel 2-morpholine carboxylic acid derivatives are described. The esters were converted into 1-aza-4-oxabicyclo[3.3.1]nonan-6-one, the first example of this ring system, which was further elaborated to the ortho-methoxy benzamide derivative (2).

  DOI：

  10.1016/s0040-4039(00)79702-4
• 作为产物：
  描述：

  1-aza-4-oxabicyclo<3.3.1>nonan-6-one 在 盐酸羟胺 作用下， 生成 4-Oxa-1-aza-bicyclo[3.3.1]nonan-6-one oxime; hydrochloride
  参考文献：
  名称：

  The synthesis of 2-morpholine carboxylic acid derivatives and their elaboration to 1-aza-4-oxabicyclo[3.3.1]nonan-6-one.

  摘要：

  Two syntheses of novel 2-morpholine carboxylic acid derivatives are described. The esters were converted into 1-aza-4-oxabicyclo[3.3.1]nonan-6-one, the first example of this ring system, which was further elaborated to the ortho-methoxy benzamide derivative (2).

  DOI：

  10.1016/s0040-4039(00)79702-4