diethyl (3-hydroxy-2-oxo-5-(trifluoromethoxy)indolin-3-yl)phosphonate | 1448903-69-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: diethyl (3-hydroxy-2-oxo-5-(trifluoromethoxy)indolin-3-yl)phosphonate
• 英文别名: 3-diethoxyphosphoryl-3-hydroxy-5-(trifluoromethoxy)-1H-indol-2-one
• CAS: 1448903-69-2
• 化学式: C₁₃H₁₅F₃NO₆P
• 分子量: 369.234
• InChiKey: DWWCAHJFTDFOIJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  94.1
• 氢给体数：
  2
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  亚磷酸二乙酯 、 5-三氟甲氧基吲哚-2,3-二酮 在 amberlyst-15 作用下， 以 neat (no solvent) 为溶剂， 反应 0.25h， 生成 diethyl (3-hydroxy-2-oxo-5-(trifluoromethoxy)indolin-3-yl)phosphonate
  参考文献：
  名称：

  Amberlyst-15 Catalyzed Synthesis of α′-Oxindole-α-Hydroxyphosphonates under Ultrasonic Irradiation

  摘要：

  An efficient and environment friendly protocol for the synthesis of -oxindole--hydroxyphosphonates by the condensation of substituted isatin and dialkylphosphite in the presence of amberlyst-15 is reported. This reaction gives good to excellent yields of products under heating and sonication conditions. Supplementary materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfer, and Silicon and the Related Elements for the following free supplemental files: Additional figures.

  DOI：

  10.1080/10426507.2012.736099

文献信息

• Amberlyst-15 Catalyzed Synthesis of α′-Oxindole-α-Hydroxyphosphonates under Ultrasonic Irradiation
  作者：Kunda Uma Maheswara Rao、Guda Dinneswara Reddy、Chan-Moon Chung

  DOI：10.1080/10426507.2012.736099

  日期：2013.8.1

  An efficient and environment friendly protocol for the synthesis of -oxindole--hydroxyphosphonates by the condensation of substituted isatin and dialkylphosphite in the presence of amberlyst-15 is reported. This reaction gives good to excellent yields of products under heating and sonication conditions. Supplementary materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfer, and Silicon and the Related Elements for the following free supplemental files: Additional figures.