Plants hydrolyze 2,4-D esters to 2,4-D, which is the active herbicide. ... Further metabolism ... occurs through three mechanisms, namely, side chain degradation, hydroxylation of the aromatic ring, and conjugation with plant constituents. /2,4-D esters/
HERBICIDAL ACTIVITY OF ESTERS, NITRILES, AMINES (&, OF COURSE, SALTS) APPEARS SIMILAR IF NOT IDENTICAL TO PARENT ACID. THIS IS APPARENTLY DUE TO PRESENCE OF HYDROLYTIC ENZYMES IN PLANTS & IN SOIL MICROORGANISMS THAT CONVERT THESE DERIVATIVES TO PARENT ACID. /2,4-D ESTERS/
2,4-D ESTERS ARE HYDROLYZED IN ANIMALS. THE PHENOXY ACIDS ARE EXCRETED PREDOMINANTLY AS SUCH IN THE URINE OF RATS AFTER THEIR ORAL ADMIN, ALTHOUGH MINOR PORTION IS CONJUGATED WITH AMINO ACIDS GLYCINE & TAURINE & WITH GLUCURONIC ACID. /2,4-D AND ESTERS/
来源:Hazardous Substances Data Bank (HSDB)
代谢
2,4-D的代谢物中，除了共轭物之外，在人类尿液中尚未被检测到。
Metabolites of 2,4-D other than conjugates have not been detected in human urine.
来源:Hazardous Substances Data Bank (HSDB)
毒理性
致癌性证据
A4；不可分类为人类致癌物。/2,4-D/
A4; Not classifiable as a human carcinogen. /2,4-D/
Classification of carcinogenicity: 1) evidence in humans: limited; overall summary evaluation of carcinogenic risk to humans is Group 2B: The agent is possibly carcinogenic to humans. /SRP: The older literature indicated that these compounds were carcinogenic. It was discovered that this was due to contamination, including dioxin./ /Chlorophenoxy herbicides; From table/
来源:Hazardous Substances Data Bank (HSDB)
毒理性
副作用
职业性肝毒素 - 第二性肝毒素：在职业环境中的毒性效应潜能是基于人类摄入或动物实验的中毒案例。
Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.
来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Cutthroat trout (Salmo clarki) were treated with six different paired mixtures of dicamba, picloram, 2,4-D butyl ester, 2,4-D isooctyl ester, and 2,4-D propylene glycol butyl ether ester. Except for 2,4-D isooctyl ester, the LC50's resulting from mixtures of 2,4-D esters and picloram were lower than LC50's of those herbicides tested individually. Dicamba and 2,4-D isooctyl ester were the least toxic individually and mixtures of dicamba or 2,4-D isooctyl ester with the other herbicides tested did not result in increased toxicity. Results reflect the importance of using combination exposures in determining the biological significance of the simultaneous occurrence of more than one herbicide in surface waters.
Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . Monitor body temperature and treat if necessary. /Chlorophenoxy herbicides and related compounds/
Leaves absorb nonpolar (ester) forms most readily. ... The esters of 2,4-D tend to resist washing from plants and are rapidly converted to the acid by the plants. ... Following foliar absorption, 2,4-D translocates within the phloem, probably moving with food material. Following root absorption, it may move upward in the transpiration stream. Translocation is influenced by the growth status of the plant. Accumulation of the herbicide occurs principally at the meristematic regions of shoots and roots. /2,4-D and its esters/
Plasma 2,4-D concn did not exceed 0.2 mg/l in workers exposed to 2,4-D ester at an atmospheric concn of 0.1 to 0.2 mg/l; no accumulation was noted during the work week. ... Workers ... developed 2,4-D urine concentrations of 3 to 14 mg/l after a day of exposure. /2,4-Dichlorophenoxyacetic acid ester/
来源:Hazardous Substances Data Bank (HSDB)
文献信息
HERBICIDAL COMPOSITIONS
申请人：Bayer Aktiengesellschaft
公开号：US20220053762A1
公开（公告）日：2022-02-24
The present invention provides compositions comprising herbicidally active compounds (A) and (B), where (A) represents one or more compounds of the general formula (I) or agrochemically compatible salts thereof [component (A)],
and (B) represents one or more herbicides [component (B)]. The application further relates to a method and to the use of the herbicidal composition according to the invention for controlling harmful plants or for regulating growth.
USE OF CERTAIN HERBICIDE COMBINATIONS BASED ON IODOSULFURON IN TEFF PLANTS
申请人：Bayer CropScience Aktiengesellschaft
公开号：EP3222143A1
公开（公告）日：2017-09-27
The present invention primarily relates to the use of specific herbicide combinations based on iodosulfuron or of a composition comprising said specific herbicide combinations for controlling harmful plants in teff (Eragrostis tef) plants. The present invention also relates to the use of specific herbicide combinations based on iodosulfuron or of a composition comprising said specific herbicide combinations as plant growth regulators for teff (Eragrostis tef) plants. Furthermore, the present invention relates to a corresponding method ofcontrolling harmful plants in teff (Eragrostis tef) plants and to a corresponding method of regulating plant growth of teff (Eragrostis tef) plants.
Use of certain herbicide combinations based on iodosulfuron in teff plants
申请人：BAYER CROPSCIENCE AKTIENGESELLSCHAFT
公开号：US10264790B2
公开（公告）日：2019-04-23
The present invention primarily relates to the use of specific herbicide combinations based on iodosulfuron or of a composition comprising said specific herbicide combinations for controlling harmful plants in teff (Eragrostis tef) plants. The present invention also relates to the use of specific herbicide combinations based on iodosulfuron or of a composition comprising said specific herbicide combinations as plant growth regulators for teff (Eragrostis tef) plants. Furthermore, the present invention relates to a corresponding method of controlling harmful plants in teff (Eragrostis tef) plants and to a corresponding method of regulating plant growth of teff (Eragrostis tef) plants.
Gegenstand der vorliegenden Erfindung sind Zusammensetzungen enthaltend herbizid wirksame Verbindungen (A) und (B), wobei (A) für eine oder mehrere Verbindungen der allgemeinen Formel (I) oder deren agrochemisch verträglichen Salze [Komponente (A)] steht, und (B) für ein oder mehreren Herbizide [Komponente (B)] steht. Die Anmeldung betrifft ferner ein Verfahren sowie die Verwendung der erfindungsgemäßen herbiziden Zusammensetzung zur Bekämpfung von Schadpflanzen oder zur Wachstumsregulierung.
