3-(9-Butylcarbazol-3-yl)-2-(4-methoxyphenyl)-1,3-thiazolidin-4-one | 1431463-61-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-(9-Butylcarbazol-3-yl)-2-(4-methoxyphenyl)-1,3-thiazolidin-4-one
• 英文别名: 3-(9-butylcarbazol-3-yl)-2-(4-methoxyphenyl)-1,3-thiazolidin-4-one
• CAS: 1431463-61-4
• 化学式: C₂₆H₂₆N₂O₂S
• 分子量: 430.571
• InChiKey: TYFQEGKNWSRQPT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  59.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-nitro-9-butylcarbazole 在 盐酸 、 tin 作用下， 以 乙醚 为溶剂， 反应 2.33h， 生成 3-(9-Butylcarbazol-3-yl)-2-(4-methoxyphenyl)-1,3-thiazolidin-4-one
  参考文献：
  名称：

  One-Pot Three-Component Mild Synthesis of 2-Aryl-3-(9-alkylcarbazol-3-yl)thiazolidin-4-ones

  摘要：

  A series of novel 2‐aryl‐3‐(9‐alkylcarbazol‐3‐yl)thiazolidin‐4‐ones were synthesized by one‐pot three‐component reactions of 3‐amino‐9‐alkylcarbazoles, aromatic aldehydes, and 2‐mercaptoacetic acid by using dicyclohexylcarbodiimide (DCC) as a cyclizing agent in dry diethyl ether at room temperature. This protocol has advantages of mild condition, short reaction time, high yield, and simple work‐up procedure.

  DOI：

  10.1002/jhet.1047

文献信息

• One-Pot Three-Component Mild Synthesis of 2-Aryl-3-(9-alkylcarbazol-3-yl)thiazolidin-4-ones
  作者：Zheng Li、Anguo Zhu、Jingya Yang

  DOI：10.1002/jhet.1047

  日期：2012.11

  A series of novel 2‐aryl‐3‐(9‐alkylcarbazol‐3‐yl)thiazolidin‐4‐ones were synthesized by one‐pot three‐component reactions of 3‐amino‐9‐alkylcarbazoles, aromatic aldehydes, and 2‐mercaptoacetic acid by using dicyclohexylcarbodiimide (DCC) as a cyclizing agent in dry diethyl ether at room temperature. This protocol has advantages of mild condition, short reaction time, high yield, and simple work‐up procedure.