甲硫美芬铵 | 4858-60-0

• 物质功能分类: 医药中间体 - 原料药中间体
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 甲硫美芬铵
• 英文名称: Mefenidramium metilsulfate
• 英文别名: 2-benzhydryloxyethyl(trimethyl)azanium;methyl sulfate
• CAS: 4858-60-0
• 化学式: C19H27NO5S
• 分子量: 381.5
• InChiKey: GTXRVYHDUSRDFT-UHFFFAOYSA-M

物化性质

• 熔点：
  135-136 °C(Solv: ethanol (64-17-5); ethyl ether (60-29-7))

计算性质

• 辛醇/水分配系数(LogP)：
  2.59
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  84
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Diagnostic/therapeutic agents
  申请人：Klaveness Jo

  公开号：US20050002865A1

  公开（公告）日：2005-01-06

  Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.

  可定位的诊断和/或治疗活性剂，例如超声对比剂，包括悬浮在水载体液中的报告物，该报告物包含含气体或生成气体的材料，该剂能够与目标形成至少两种结合对。
• Compositions and methods for the treatment of pain
  申请人：GM Pharmaceuticals, Inc.

  公开号：US10987365B2

  公开（公告）日：2021-04-27

  The claimed invention relates to compositions that may be in a form of a liquid, solid, gel, cream or gel capsule comprising an analgesic, and methods for administering these compositions for treatment of patients suffering from various forms of pain.

  本发明涉及可为液体、固体、凝胶、乳膏或凝胶胶囊形式的包含镇痛剂的组合物，以及使用这些组合物治疗各种形式疼痛患者的方法。
• PHARMACEUTICAL COMPOSITIONS INCLUDING AN ANTIHISTAMINE AND A STIMULANT AND USE THEREOF
  申请人：Pediamed Pharmaceuticals, Inc.

  公开号：EP1641446A1

  公开（公告）日：2006-04-05
• Pharmaceutical compositions including an antihistamine and a stimulant and method of use thereof
  申请人：PediaMed Pharmaceuticals, Inc.

  公开号：US20040259809A1

  公开（公告）日：2004-12-23

  The present invention provides pharmaceutical compositions including a sedating antihistamine and a stimulant, and methods of use thereof. The stimulant reduces the sedation caused by the antihistamine, thereby allowing potent, but sedating, antihistamines to be used effectively.
• Methods and devices for the treatment of ocular conditions
  申请人：deJuan Eugene

  公开号：US20060110428A1

  公开（公告）日：2006-05-25

  Featured is a method for instilling one or more bioactive agents into ocular tissue within an eye of a patient for the treatment of an ocular condition, the method comprising concurrently using at least two of the following bioactive agent delivery methods (A)-(C): (A) implanting a sustained release delivery device comprising one or more bioactive agents in a posterior region of the eye so that it delivers the one or more bioactive agents into the vitreous humor of the eye; (B) instilling (e.g., injecting or implanting) one or more bioactive agents subretinally; and (C) instilling (e.g., injecting or delivering by ocular iontophoresis) one or more bioactive agents into the vitreous humor of the eye.