5-Bromo-2-[fluoro(pyridin-2-ylsulfonyl)methyl]pyridine | 1415115-23-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5-Bromo-2-[fluoro(pyridin-2-ylsulfonyl)methyl]pyridine
• 英文别名: 5-bromo-2-[fluoro(pyridin-2-ylsulfonyl)methyl]pyridine
• CAS: 1415115-23-9
• 化学式: C₁₁H₈BrFN₂O₂S
• 分子量: 331.165
• InChiKey: BPCQDLNXGPDGEX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  68.3
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  氟甲基2-吡啶基砜 在 N-碘代丁二酰亚胺 、 potassium tert-butylate 、 diethylzinc 作用下， 以 正己烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 8.83h， 生成 5-Bromo-2-[fluoro(pyridin-2-ylsulfonyl)methyl]pyridine
  参考文献：
  名称：

  Copper-Mediated Fluoroalkylation of Aryl Iodides Enables Facile Access to Diverse Fluorinated Compounds: The Important Role of the (2-Pyridyl)sulfonyl Group

  摘要：

  The (2-pyridyl)sulfonyl group was found to be a multifunctional group in the preparation of structurally diverse fluorinated products. It not only facilitates the copper-mediated (or catalyzed) cross-coupling reaction between a-fluoro sulfone 4a and aryl iodides, but also enables further transformations of the coupling products 2.

  DOI：

  10.1021/ol3029737

文献信息

• Copper-Mediated Fluoroalkylation of Aryl Iodides Enables Facile Access to Diverse Fluorinated Compounds: The Important Role of the (2-Pyridyl)sulfonyl Group
  作者：Yanchuan Zhao、Bing Gao、Chuanfa Ni、Jinbo Hu

  DOI：10.1021/ol3029737

  日期：2012.12.7

  The (2-pyridyl)sulfonyl group was found to be a multifunctional group in the preparation of structurally diverse fluorinated products. It not only facilitates the copper-mediated (or catalyzed) cross-coupling reaction between a-fluoro sulfone 4a and aryl iodides, but also enables further transformations of the coupling products 2.