4-(2-chlorobenzyl)-1,2-dihydro-2,2-dimethyl-4H-benzo[e][1,4]diazepine-3,5-dione | 1416791-86-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: 4-(2-chlorobenzyl)-1,2-dihydro-2,2-dimethyl-4H-benzo[e][1,4]diazepine-3,5-dione
• 英文别名: 4-[(2-chlorophenyl)methyl]-2,2-dimethyl-1H-1,4-benzodiazepine-3,5-dione
• CAS: 1416791-86-0
• 化学式: C₁₈H₁₇ClN₂O₂
• 分子量: 328.798
• InChiKey: TUJUDSQGQYFFQA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  邻氯苯甲胺 以 水 为溶剂， 反应 3.0h， 生成 4-(2-chlorobenzyl)-1,2-dihydro-2,2-dimethyl-4H-benzo[e][1,4]diazepine-3,5-dione
  参考文献：
  名称：

  Synthesis of Novel 1,4-Benzodiazepine-3,5-dione Derivatives: Reaction of 2-Aminobenzamides under Bargellini Reaction Conditions

  摘要：

  In this paper, we report on a user-friendly synthesis of 1,4-benzodiazepine- 3,5- dione derivatives via Bargellini-type reaction. The corresponding products were obtained using various 2-aminobenzamides under Bargellini reaction conditions, in good yields without unfavorable side reaction.

  DOI：

  10.1055/s-0032-1317297

文献信息

• Synthesis of Novel 1,4-Benzodiazepine-3,5-dione Derivatives: Reaction of 2-Aminobenzamides under Bargellini Reaction Conditions
  作者：Abbas Shafiee、Mohammad Mahdavi、Mehdi Asadi、Mina Saeedi、Zahra Rezaei、Hooman Moghbel、Alireza Foroumadi

  DOI：10.1055/s-0032-1317297

  日期：——

  In this paper, we report on a user-friendly synthesis of 1,4-benzodiazepine- 3,5- dione derivatives via Bargellini-type reaction. The corresponding products were obtained using various 2-aminobenzamides under Bargellini reaction conditions, in good yields without unfavorable side reaction.