(2R,3aR,4R,5R,6R)-4,5-Bis(benzyloxy)-6-[(benzyloxy)methyl]-2-[(2,6-dimethylphenoxy)methyl]hexahydropyrrolo[1,2-b]-isoxazole | 1386987-66-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2R,3aR,4R,5R,6R)-4,5-Bis(benzyloxy)-6-[(benzyloxy)methyl]-2-[(2,6-dimethylphenoxy)methyl]hexahydropyrrolo[1,2-b]-isoxazole
• 英文别名: (2R,3aR,4R,5R,6R)-2-[(2,6-dimethylphenoxy)methyl]-4,5-bis(phenylmethoxy)-6-(phenylmethoxymethyl)-2,3,3a,4,5,6-hexahydropyrrolo[1,2-b][1,2]oxazole
• CAS: 1386987-66-1
• 化学式: C₃₇H₄₁NO₅
• 分子量: 579.736
• InChiKey: XTBOQQVCLSXEGI-VVJLNTFGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  43
• 可旋转键数：
  13
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  49.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (2R,3aR,4R,5R,6R)-4,5-Bis(benzyloxy)-6-[(benzyloxy)methyl]-2-[(2,6-dimethylphenoxy)methyl]hexahydropyrrolo[1,2-b]-isoxazole 在 盐酸 、 palladium on activated charcoal 、 氢气 作用下， 以 甲醇 为溶剂， 反应 15.0h， 以97%的产率得到(2R,3R,4R,5R)-2-[(2R)-3-(2,6-dimethylphenoxy)-2-hydroxypropyl]-5-(hydroxymethyl)pyrrolidine-3,4-diol
  参考文献：
  名称：

  Building Multivalent Iminosugar-Based Ligands on Calixarene Cores via Nitrone Cycloadditions

  摘要：

  A novel and challenging approach for the construction of multivalent iminosugar architectures directly on calixarene scaffolds is presented, which exploits multiple cycloaddition reactions of a carbohydrate-derived nitrone on diversely functionalized calix[4]arenes. Regardless of the 4-fold reiteration on a single calixarene, the reactions take place with high regio- and stereoselectivity, demonstrating this method as an appealing one for the synthesis of calixarene-based neoglycoconjugates.

  DOI：

  10.1021/jo301155p
• 作为产物：
  描述：

  烯丙基2,6-二甲基苯基醚 、 (2R,3R,4R)-3,4-bis(benzyloxy)-2-((benzyloxy)methyl)-3,4-dihydro-2H-pyrrole 1-oxide 以 甲苯 为溶剂， 反应 24.0h， 以52%的产率得到(2R,3aR,4R,5R,6R)-4,5-Bis(benzyloxy)-6-[(benzyloxy)methyl]-2-[(2,6-dimethylphenoxy)methyl]hexahydropyrrolo[1,2-b]-isoxazole
  参考文献：
  名称：

  Building Multivalent Iminosugar-Based Ligands on Calixarene Cores via Nitrone Cycloadditions

  摘要：

  A novel and challenging approach for the construction of multivalent iminosugar architectures directly on calixarene scaffolds is presented, which exploits multiple cycloaddition reactions of a carbohydrate-derived nitrone on diversely functionalized calix[4]arenes. Regardless of the 4-fold reiteration on a single calixarene, the reactions take place with high regio- and stereoselectivity, demonstrating this method as an appealing one for the synthesis of calixarene-based neoglycoconjugates.

  DOI：

  10.1021/jo301155p

文献信息

• Building Multivalent Iminosugar-Based Ligands on Calixarene Cores via Nitrone Cycloadditions
  作者：Francesca Cardona、Giovanni Isoldi、Francesco Sansone、Alessandro Casnati、Andrea Goti

  DOI：10.1021/jo301155p

  日期：2012.8.17

  A novel and challenging approach for the construction of multivalent iminosugar architectures directly on calixarene scaffolds is presented, which exploits multiple cycloaddition reactions of a carbohydrate-derived nitrone on diversely functionalized calix[4]arenes. Regardless of the 4-fold reiteration on a single calixarene, the reactions take place with high regio- and stereoselectivity, demonstrating this method as an appealing one for the synthesis of calixarene-based neoglycoconjugates.