2,2,2-trifluoroethyl 2-(4-bromo-N-[(E)-3-phenylprop-2-enoyl]anilino)-2-phenylacetate | 1407150-74-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2,2,2-trifluoroethyl 2-(4-bromo-N-[(E)-3-phenylprop-2-enoyl]anilino)-2-phenylacetate
• CAS: 1407150-74-6
• 化学式: C₂₅H₁₉BrF₃NO₃
• 分子量: 518.33
• InChiKey: IFMATWKEONUOHS-LFIBNONCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  33
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2,2,2-三氟乙醇 、 (E)-N-(4-bromophenyl)-N-[2-(tert-butylamino)-2-oxo-1-phenylethyl]-3-phenylprop-2-enamide 在 硫酸 作用下， 反应 0.17h， 生成 2,2,2-trifluoroethyl 2-(4-bromo-N-[(E)-3-phenylprop-2-enoyl]anilino)-2-phenylacetate
  参考文献：
  名称：

  A facile and efficient synthesis of 2,2,2-trifluoroethyl 2-[(E)-N-phenylcinnamamido]-2-phenylacetates in trifluoroethanol via sequential Ugi four-component reaction/esterification

  摘要：

  We describe an efficient approach for the synthesis of N-substituted 2-alkenylamides in trifluoroethanol via an Ugi 4-component reaction in short reaction times. The use of a catalytic amount of sulfuric acid in trifluoroethanol gave the desired trifluoroethyl derivatives in good to high yields. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.08.096

文献信息

• A facile and efficient synthesis of 2,2,2-trifluoroethyl 2-[(E)-N-phenylcinnamamido]-2-phenylacetates in trifluoroethanol via sequential Ugi four-component reaction/esterification
  作者：Saeed Balalaie、Hassan Motaghedi、Daryoush Tahmassebi、Morteza Bararjanian、Hamid Reza Bijanzadeh

  DOI：10.1016/j.tetlet.2012.08.096

  日期：2012.11

  We describe an efficient approach for the synthesis of N-substituted 2-alkenylamides in trifluoroethanol via an Ugi 4-component reaction in short reaction times. The use of a catalytic amount of sulfuric acid in trifluoroethanol gave the desired trifluoroethyl derivatives in good to high yields. (C) 2012 Elsevier Ltd. All rights reserved.