Ethyl 11-benzyl-15-bromo-10-oxo-11-azatetracyclo[7.6.1.02,7.012,16]hexadeca-1(15),2,4,6,8,12(16),13-heptaene-8-carboxylate | 1400564-41-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: Ethyl 11-benzyl-15-bromo-10-oxo-11-azatetracyclo[7.6.1.02,7.012,16]hexadeca-1(15),2,4,6,8,12(16),13-heptaene-8-carboxylate
• 英文别名: ethyl 11-benzyl-15-bromo-10-oxo-11-azatetracyclo[7.6.1.02,7.012,16]hexadeca-1(15),2,4,6,8,12(16),13-heptaene-8-carboxylate
• CAS: 1400564-41-1
• 化学式: C₂₅H₁₈BrNO₃
• 分子量: 460.327
• InChiKey: TUPADAWVMHPDDR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3,3-dibenzyl-2-ethyl-(1R,2S,5R)-1′-benzyl-5′-bromo-5-(2-methoxy-2-oxoethyl)-2′-oxospiro[cyclopentane-1,3′-indoline] 2,3,3-tricarboxylate 、 2-(trimethylsilyl)phenyl 4-methylbenzenesulfonate 在 cesium fluoride 作用下， 以 乙腈 为溶剂， 反应 12.0h， 以80%的产率得到Ethyl 11-benzyl-15-bromo-10-oxo-11-azatetracyclo[7.6.1.02,7.012,16]hexadeca-1(15),2,4,6,8,12(16),13-heptaene-8-carboxylate
  参考文献：
  名称：

  Construction of Naphtho-Fused Oxindolesviathe Aryne Diels–Alder Reaction with Methyleneindolinones

  摘要：

  Unprecedented aryne Diels-Alder reactions by using methyleneindolinones as dienes have been disclosed, thus providing a quick access to unusual naphtho-fused oxindoles. A wide range of methyleneindolinones proceed readily with arynes to afford the functionalized oxindoles in good yields.

  DOI：

  10.1021/ol3018787

文献信息

• Construction of Naphtho-Fused Oxindoles<i>via</i>the Aryne Diels–Alder Reaction with Methyleneindolinones
  作者：Jian Li、Ning Wang、Chunju Li、Xueshun Jia

  DOI：10.1021/ol3018787

  日期：2012.10.5

  Unprecedented aryne Diels-Alder reactions by using methyleneindolinones as dienes have been disclosed, thus providing a quick access to unusual naphtho-fused oxindoles. A wide range of methyleneindolinones proceed readily with arynes to afford the functionalized oxindoles in good yields.