N-(3-fluorophenyl)-4-(4-morpholin-4-ylphenyl)-1,3-thiazol-2-amine | 1415695-53-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: N-(3-fluorophenyl)-4-(4-morpholin-4-ylphenyl)-1,3-thiazol-2-amine
• CAS: 1415695-53-2
• 化学式: C₁₉H₁₈FN₃OS
• 分子量: 355.436
• InChiKey: DVNUHKCQBOQYKF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  65.6
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  1-(3-氟苯基)-2-硫脲 、 Alpha-溴代-4-吗啡啉苯乙酮 以 乙醇 为溶剂， 反应 0.5h， 以20%的产率得到N-(3-fluorophenyl)-4-(4-morpholin-4-ylphenyl)-1,3-thiazol-2-amine
  参考文献：
  名称：

  Design and synthesis of 2-aminothiazole based antimicrobials targeting MRSA

  摘要：

  Privileged structure-based libraries have been shown to provide high affinity lead compounds for a variety of important biological targets. The present study describes the synthesis and screening of a 2-aminothiazole based compound library to determine their utility as antimicrobials, focusing on MRSA. Several of the compounds in this series demonstrated improved antimicrobial activity as compared to ceftriaxone (CTX), a beta-lactam antibiotic. The most potent compound (21) had MICs in the range of 24 mu g/ml across a panel of Staphylococcus aureus strains. In addition, trifluoromethoxy substituted aminothiazoles and aminobenzothiazoles were found to be potent antimicrobials with MICs of 2-16 mu g/ml. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.09.095