2,2'-[(Thiophen-2-yl)methylene]bis(1-methyl-1H-pyrrole) | 919295-55-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 2,2'-[(Thiophen-2-yl)methylene]bis(1-methyl-1H-pyrrole)
• 英文别名: 1-methyl-2-[(1-methylpyrrol-2-yl)-thiophen-2-ylmethyl]pyrrole
• CAS: 919295-55-9
• 化学式: C₁₅H₁₆N₂S
• 分子量: 256.371
• InChiKey: YUIXIIOVFLYTBS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  38.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-甲基吡咯 、 2-噻吩甲醛 在 Amberlyst 15 ion exchange resin 作用下， 以68%的产率得到2,2'-[(Thiophen-2-yl)methylene]bis(1-methyl-1H-pyrrole)
  参考文献：
  名称：

  Unique versatility of Amberlyst 15. An acid and solvent-free paradigm towards synthesis of bis(heterocyclyl)methane derivatives

  摘要：

  Bis(heterocyclyl)methanes, key intermediates for a variety of chemical, biochemical and material science relevant targets, have been obtained in a synthetically useful manner using Amberlyst 15 ion-exchange resin. This method promises versatility, cost-effectiveness, and efficiency. (C) 2011 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molcata.2011.07.007

文献信息

• Organocatalytic synthesis of dipyrromethanes by the addition of N-methylpyrrole to aldehydes
  作者：Cinzia Biaggi、Maurizio Benaglia、Laura Raimondi、Franco Cozzi

  DOI：10.1016/j.tet.2006.09.104

  日期：2006.12

  The reaction of aldehydes with N-methylpyrrole carried out in the presence of catalytic pyrrolidinium tetrafluoroborate at room temperature affords the corresponding dipyrromethanes and minor amounts of tripyrranes. This new, mild, and convenient process represents the first organocatalytic synthesis of dipyrromethanes. The products are obtained in chemical yields similar to those obtained with existing methods, which, however, require either a much larger excess of heterocycle (when aldehydes are employed as starting materials), or more drastic reaction conditions (when aldehyde equivalents are used as starting materials) than those employed here. A mechanism is proposed to explain the course of this reaction. (c) 2006 Elsevier Ltd. All rights reserved.
• Unique versatility of Amberlyst 15. An acid and solvent-free paradigm towards synthesis of bis(heterocyclyl)methane derivatives
  作者：Kamaljit Singh、Shivali Sharma、Amit Sharma

  DOI：10.1016/j.molcata.2011.07.007

  日期：2011.8

  Bis(heterocyclyl)methanes, key intermediates for a variety of chemical, biochemical and material science relevant targets, have been obtained in a synthetically useful manner using Amberlyst 15 ion-exchange resin. This method promises versatility, cost-effectiveness, and efficiency. (C) 2011 Elsevier B.V. All rights reserved.