3-对联苯基-3-甲基丁酸 | 81770-17-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3-对联苯基-3-甲基丁酸
• 英文名称: 3-p-biphenylyl-3-methylbutanoic acid
• 英文别名: 3-Methyl-3-(4-phenylphenyl)butanoic acid
• CAS: 81770-17-4
• 化学式: C₁₇H₁₈O₂
• mdl: MFCD21993519
• 分子量: 254.329
• InChiKey: SWKIHVIFGMBDEB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.235
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-(3-fluorophenyl)-2-[(2S)-pyrrolidin-2-yl]-1H-imidazole;hydrochloride 、 3-对联苯基-3-甲基丁酸 在 N,N-二异丙基乙胺 、 Methanaminium,N-[(dimethylamino)(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methyl-, hexafluorophosphate(1-) 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 生成 3-(biphenyl-4-yl)-1-{2-[5-(3-fluorophenyl)-1H-imidazol-2-yl]-pyrrolidin-1-yl}-2,2-dimethylpropan-1-one
  参考文献：
  名称：

  Design and Synthesis of Prolylcarboxypeptidase (PrCP) Inhibitors To Validate PrCP As A Potential Target for Obesity

  摘要：

  Prolycarboxypeptidase (PrCP) is a serine protease that may have a role in metabolism regulation. A class of reversible, potent, and selective PrCP inhibitors was developed starting from a mechanism based design for inhibiting this serine protease. Compound 8o inhibits human and mouse PrCP at IC(50) values of 1 and 2 nM and is not active (IC(50) > 25 mu M) against a panel of closely related proteases. It has lower serum binding than its close analogues and is bioavailable in mouse. Subchronic dosing of 8o in PrCP and WT mice at 100 mg/kg for 5 days resulted in a 5% reduction in body weight in WT mice and a reduction in PrCP KO mice.

  DOI：

  10.1021/jm101013m
• 作为产物：
  描述：

  2-p-biphenylyl-1-chloro-2-methylpropane 、 四氢呋喃 生成 3-对联苯基-3-甲基丁酸
  参考文献：
  名称：

  GROVENSTEIN, E. ,, JR;LU, PANG-CHIA, J. ORG. CHEM., 1982, 47, N 15, 2928-2939

  摘要：

  DOI：

文献信息

• Carbanions. 21. Reactions of 2- and 3-p-biphenylylalkyl chlorides with alkali metals. Preparation of labile spiro anions
  作者：Erling Grovenstein、Pang Chia Lu

  DOI：10.1021/jo00136a025

  日期：1982.7
• Design and Synthesis of Prolylcarboxypeptidase (PrCP) Inhibitors To Validate PrCP As A Potential Target for Obesity
  作者：Changyou Zhou、Margareta Garcia-Calvo、Shirly Pinto、Matthew Lombardo、Zhe Feng、Kate Bender、KellyAnn D. Pryor、Urmi R. Bhatt、Renee M. Chabin、Wayne M. Geissler、Zhu Shen、Xinchun Tong、Zhoupeng Zhang、Kenny K. Wong、Ranabir Sinha Roy、Kevin T. Chapman、Lihu Yang、Yusheng Xiong

  DOI：10.1021/jm101013m

  日期：2010.10.14

  Prolycarboxypeptidase (PrCP) is a serine protease that may have a role in metabolism regulation. A class of reversible, potent, and selective PrCP inhibitors was developed starting from a mechanism based design for inhibiting this serine protease. Compound 8o inhibits human and mouse PrCP at IC(50) values of 1 and 2 nM and is not active (IC(50) > 25 mu M) against a panel of closely related proteases. It has lower serum binding than its close analogues and is bioavailable in mouse. Subchronic dosing of 8o in PrCP and WT mice at 100 mg/kg for 5 days resulted in a 5% reduction in body weight in WT mice and a reduction in PrCP KO mice.
• GROVENSTEIN, E. ,, JR;LU, PANG-CHIA, J. ORG. CHEM., 1982, 47, N 15, 2928-2939
  作者：GROVENSTEIN, E. ,, JR、LU, PANG-CHIA

  DOI：——

  日期：——