[EN] ISOINDOLINONE COMPOUNDS AND IMAGING AGENTS FOR IMAGING HUNTINGTIN PROTEIN [FR] COMPOSÉS D'ISOINDOLINONE ET AGENTS D'IMAGERIE POUR L'IMAGERIE DE LA PROTÉINE HUNTINGTINE
COMPOUNDS FOR USING IN IMAGING AND PARTICULARLY FOR THE DIAGNOSIS OF NEURODEGENERATIVE DISEASES
申请人:CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
公开号:US20190211011A1
公开(公告)日:2019-07-11
The invention relates to compounds of formula (II) for using in imaging and particularly for the diagnosis of neurodegenerative diseases
该发明涉及公式(II)的化合物,用于影像学,特别是用于诊断神经退行性疾病。
Indole derivatives
申请人:GE Healthcare Limited
公开号:US09220795B2
公开(公告)日:2015-12-29
An indole-based in vivo imaging agent is provided by the present invention that binds with high affinity to PBR, has good uptake into the brain following administration, and which has good selective binding to PBR. The invention also includes a precursor compound useful in the synthesis of the in vivo imaging agent of the invention, as well as a method for synthesis of said in vivo imaging agent comprising use of said precursor compound, and a kit for carrying out said method. Also provided is a cassette for automated synthesis of the in vivo imaging agent. Further aspects of the invention include a radiopharmaceutical composition comprising the in vivo imaging agent of the invention, and methods for the use of said in vivo imaging agent.
SYNTHESIZING PET TRACERS USING [F-18]SULFONYL FLUORIDE AS A SOURCE OF [F-18]FLUORIDE
申请人:Zhou Dong
公开号:US20170197912A1
公开(公告)日:2017-07-13
The present disclosure relates to the methods for the preparation of reactive [F-18]fluoride in a form of [F-18]sulfonyl fluoride suitable for efficient radiolabeling without an azeotropic evaporation step by the use of anion exchange resin and sulfonyl chloride, and its applications in the manufacturing of PET radiopharmaceuticals.
[EN] RADIOLABELED COMPOUNDS THAT TARGET ORGANIC CATION TRANSPORTERS AND USES THEREOF IN RADIOIMAGING<br/>[FR] COMPOSÉS RADIOMARQUÉS CIBLANT DES TRANSPORTEURS DE CATIONS ORGANIQUES ET LEURS UTILISATIONS EN RADIOIMAGERIE
申请人:HADASIT MED RES SERVICE
公开号:WO2018207193A1
公开(公告)日:2018-11-15
Radiolabeled quaternary ammonium salt compounds featuring a quinoline skeleton and uses thereof in radioimaging are provided. The radiolabeled compounds are usable for determining a presence and/or level and/or distribution of an organic cation transporter in a body of a patient and for determining if the patient has a disease or disorder that is treatable by or responsive to a therapy whose efficacy correlates with a presence and/or level of an organic cation transporter. Also provided is a use of these radiolabeled compounds in treating such a disease or disorder. The radiolabeled compounds are also usable for radioimaging OCT- expressing cells, tissues and/or organ, for determining a presence and/or level of an impaired structure or function of the OCT-expressing cells, tissues and/or organ and/or of a disease or disorder associated with such impaired structure and/or function.
The present invention provides a method useful in the diagnosis and/or monitoring of mood disorders wherein there is an abnormal expression of PBR. The method of the invention is useful in the differential diagnosis of said mood disorders and other conditions where there is no abnormal expression of PBR but where the symptoms may be similar to those of said mood disorder.