3-氧代-2-苯基丙烯酰氯化物 | 17118-70-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3-氧代-2-苯基丙烯酰氯化物
• 英文名称: (chlorocarbonyl)phenyl ketene
• 英文别名: 3-Oxo-2-phenylprop-2-enoyl chloride
• CAS: 17118-70-6
• 化学式: C₉H₅ClO₂
• 分子量: 180.59
• InChiKey: ZEHCNHDIBSTCCY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-氧代-2-苯基丙烯酰氯化物 在 三乙胺 、 锌 作用下， 以 四氢呋喃 、 乙醚 、 溶剂黄146 为溶剂， 反应 0.5h， 生成 N,N-二甲基-2-苯基乙酰胺
  参考文献：
  名称：

  Zvilichovsky, Gury, Journal of Heterocyclic Chemistry, 1987, vol. 24, p. 465 - 470

  摘要：

  DOI：
• 作为产物：
  描述：

  苯丙二酸 在 氯化亚砜 作用下， 以 甲苯 为溶剂， 反应 24.0h， 生成 3-氧代-2-苯基丙烯酰氯化物
  参考文献：
  名称：

  A One Pot Synthesis of 5-Phenyl-1,3-Dioxane-4,6-Dione Derivatives

  摘要：

  A general procedure for synthesis of 5-phenyl-1,3-dioxane-4,6-dione derivatives is described. The synthesis involves the cycloaddition of (alpha - chlorocarbonyl)phenylketene with carbonyl compounds to generate the corresponding substituted 2-oxetanone's which is readily transformed to the final products in one step. The 1,3-dioxane-4,6-dione is a rigid cyclic structure, and can undergo easy hydrolysis.

  DOI：

  10.1080/00397910008086875

文献信息

• Reaction of α-oxoketenes with 2-substituted benzothiazoles and benzimidazoles: synthesis of benzo[4,5]thiazolo[3,2-a]pyridinone and N-(1,3-benzothiazol-2-yl)-3-oxopropanamide derivatives
  作者：Mahboobeh Zahedifar、Hassan Sheibani

  DOI：10.1007/s10593-016-1829-3

  日期：2016.1

  cyclocondensation reactions of α-oxoketenes with 2-substituted benzothiazoles have been investigated. Acyl-substituted Meldrum's acids and 1,3-dioxin-4-one derivatives have been used as starting compounds for preparation of α-oxoketenes, which were used in the cycloaddition reactions with (benzothiazol-2-yl)-acetonitrile and (benzimidazol-2-yl)acetonitrile giving good product yields. Also the reaction of (ch

  已经研究了通过α-氧杂环丁烯与2-取代的苯并噻唑的环缩合反应合成嘧啶酮衍生物的快速简便的方法。酰基取代的麦德鲁姆酸和1,3-二恶英-4-酮衍生物已用作制备α-氧杂环丁烯的起始化合物，它们用于与（苯并噻唑-2-基）-乙腈和（苯并咪唑- 2-基）乙腈提供良好的产物收率。还研究了（氯羰基）苯乙烯酮与2-（1,3-苯并噻唑-2-基）乙腈的反应。
• Antibacterial 3-(5-tetrazolyl) penam compounds
  申请人：Pfizer Inc.

  公开号：US04115385A1

  公开（公告）日：1978-09-19

  Certain novel 6-acylamino-2,2-dimethyl-3-(5-tetrazolyl)penam derivatives, and salts thereof; their use as broad-spectrum antibacterial agents; and methods for their preparation. Their preparation comprises acylation of the novel intermediate, 6-amino-2,2-dimethyl-3-(5-tetrazolyl)penam or simple derivatives thereof, followed, in some cases, by further transformations of the 6-acylamino group or by removal of a protecting group from the 5-tetrazolyl moiety. Process for the preparation of 6-amino-2,2-dimethyl-3-(5-tetrazolyl)penam, simple derivatives thereof and intermediates therefor.

  某些新型6-酰氨基-2,2-二甲基-3-(5-四唑基)佩纳姆衍生物及其盐；它们作为广谱抗菌剂的用途；以及它们的制备方法。它们的制备包括对新型中间体6-氨基-2,2-二甲基-3-(5-四唑基)佩纳姆或其简单衍生物进行酰化，然后在某些情况下，通过进一步转化6-酰氨基基团或去除5-四唑基团的保护基来进行。制备6-氨基-2,2-二甲基-3-(5-四唑基)佩纳姆、其简单衍生物及其中间体的方法。
• Antibacterial 3-(5-tetrazolyl)penam compounds
  申请人：Pfizer Inc.

  公开号：US04143039A1

  公开（公告）日：1979-03-06

  Certain novel 6-acylamino-2,2-dimethyl-3-(5-tetrazolyl)penam derivatives, and salts thereof; their use as broad-spectrum antibacterial agents; and methods for their preparation. Their preparation comprises acylation of the novel intermediate, 6-amino-2,2-dimethyl-3-(5-tetrazolyl)penam or simple derivatives thereof, followed, in some cases, by further transformations of the 6-acylamino group or by removal of a protecting group from the 5-tetrazolyl moiety. Process for the preparation of 6-amino-2,2-dimethyl-3-(5-tetrazolyl)penam, simple derivatives thereof and intermediates therefor.

  某些新型6-酰氨基-2,2-二甲基-3-(5-四唑基)佩纳姆衍生物及其盐；它们作为广谱抗菌剂的用途；以及它们的制备方法。它们的制备包括对新型中间体6-氨基-2,2-二甲基-3-(5-四唑基)佩纳姆或其简单衍生物进行酰化，然后，在某些情况下，通过进一步转化6-酰氨基基团或去除5-四唑基团的保护基来进行。制备6-氨基-2,2-二甲基-3-(5-四唑基)佩纳姆、其简单衍生物及其中间体的方法。
• Preparation of Arylpropynamides and Their Reaction with Malonyl Acid Derivatives
  作者：Olga Petina、Igor Yakovlev、Detlef Geffken

  DOI：10.1055/s-0032-1316851

  日期：——

  4-hydroxy-2-(phenylethynyl)-6H-1,3-oxazin-6-ones; and the reaction of arylpropynamides with disubstituted malonyl chlorides furnished open-chain arylpropenamides exclusively. Synthesis of arylpropynamides and their reactions with different malonic acid derivatives is described. Treatment of arylpropynamides with unsubstituted malonyl chloride furnished N-(3-arylprop-2-ynoyl)-6-chloro-4-hydroxy-2-oxo-2H-pyran-3-carboxamides;

  摘要 描述了芳基丙炔酰胺的合成及其与不同丙二酸衍生物的反应。未取代的丙二酰氯配arylpropynamides的治疗ñ - （3- arylprop -2-炔酰基）-6-氯-4-羟基-2-氧代-2- ħ -吡喃-3-羧酰胺; 将单取代的丙二酰氯或其衍生物（氯羰基）乙基乙烯酮与芳基丙炔酰胺反应，得到4-羟基-2-（苯基乙炔基）-6 H -1,3-恶嗪-6-酮；芳基丙酰胺与二取代的丙二酰氯的反应仅提供开链芳基丙烯酰胺。 描述了芳基丙炔酰胺的合成及其与不同丙二酸衍生物的反应。未取代的丙二酰氯配arylpropynamides的治疗ñ - （3- arylprop -2-炔酰基）-6-氯-4-羟基-2-氧代-2- ħ -吡喃-3-羧酰胺; 将单取代的丙二酰氯或其衍生物（氯羰基）乙基乙烯酮与芳基丙炔酰胺反应，得到4-羟基-2-（苯基乙炔基）-6 H -1,3-恶嗪-6-酮；芳基丙酰胺与二取代的丙二酰氯的反应仅提供开链芳基丙烯酰胺。
• A Convenient One-Pot Synthesis of Pyrano[3,2-<i>c</i>]quinolin-2,5(6<i>H</i>)-dione and 2<i>H</i>,5<i>H</i>-Pyrano[3,2-<i>c</i>]chromene-2,5-dione Derivatives
  作者：Hassan Sheibani、Mohammad Hossein Mosslemin、Soheila Behzadi、Mohammad Reza Islami、Kazem Saidi

  DOI：10.1055/s-2006-926295

  日期：——

  The preparation of novel pyrano[3,2-c]quinolin-2,5(6H)-dione and 2H,5H-pyrano[3,2-c]chromene-2,5-dione derivatives starting from 4-hydroxyquinolin-2(1H)-ones and 4-hydroxy-2H-chromene-2-one with chlorocarbonyl ketenes is described. This method provides a new route to produce fused pyrano derivatives in good to excellent yields in a short experimental time.

  报道了以4-羟基喹啉-2(1H)-酮和4-羟基-2H-色烯-2-酮为起始物，通过氯代碳酰基烯酮合成新型吡喃并[3,2-c]喹啉-2,5(6H)-二酮和2H,5H-吡喃并[3,2-c]色烯-2,5-二酮衍生物的方法。该方法提供了一条在短时间内以良好至优异收率制备融合吡喃衍生物的新途径。