1,1-Bis-((R)-1-phenyl-ethyl)-urea | 600728-22-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,1-Bis-((R)-1-phenyl-ethyl)-urea
• 英文别名: N,N-Bis[(1R)-1-phenylethyl]urea；1,1-bis[(1R)-1-phenylethyl]urea
• CAS: 600728-22-1
• 化学式: C₁₇H₂₀N₂O
• 分子量: 268.359
• InChiKey: JZMDIPSRFRIVQH-ZIAGYGMSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  46.3
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1,1-Bis-((R)-1-phenyl-ethyl)-urea 在 titanium(IV) isopropylate 、 potassium carbonate 、 间氯过氧苯甲酸 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 (3R)-3-(4-chlorophenyl)-N,N-bis[(1R)-1-phenylethyl]oxaziridine-2-carboxamide
  参考文献：
  名称：

  Efficient nitrogen transfer from aldehyde-derived N-acyloxaziridines

  摘要：

  The effect of solvent polarity on the reaction of 3-aryl-N-carboxamido- and 3-aryl-N-alkoxycarbonyl oxaziridines has been studied and an efficient procedure for high yielding sulfimidation developed by use of polar solvents. The first examples of asymmetric sulfimidation using novel chiral oxaziridines have been carried out with low diastereoselectivity (up to 30% de). (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(03)01200-0
• 作为产物：
  描述：

  三光气 、 (+)-双[(R)-1-苯乙基]胺 在 4-二甲氨基吡啶 、 三光气 、 三乙胺 、 氨 作用下， 以 乙醚 为溶剂， 生成 1,1-Bis-((R)-1-phenyl-ethyl)-urea
  参考文献：
  名称：

  Efficient nitrogen transfer from aldehyde-derived N-acyloxaziridines

  摘要：

  The effect of solvent polarity on the reaction of 3-aryl-N-carboxamido- and 3-aryl-N-alkoxycarbonyl oxaziridines has been studied and an efficient procedure for high yielding sulfimidation developed by use of polar solvents. The first examples of asymmetric sulfimidation using novel chiral oxaziridines have been carried out with low diastereoselectivity (up to 30% de). (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(03)01200-0

文献信息

• Efficient nitrogen transfer from aldehyde-derived N-acyloxaziridines
  作者：Alan Armstrong、Ian D. Edmonds、Martin E. Swarbrick

  DOI：10.1016/s0040-4039(03)01200-0

  日期：2003.7

  The effect of solvent polarity on the reaction of 3-aryl-N-carboxamido- and 3-aryl-N-alkoxycarbonyl oxaziridines has been studied and an efficient procedure for high yielding sulfimidation developed by use of polar solvents. The first examples of asymmetric sulfimidation using novel chiral oxaziridines have been carried out with low diastereoselectivity (up to 30% de). (C) 2003 Elsevier Science Ltd. All rights reserved.