甲酸2-甲氧基乙酯 | 628-82-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 甲酸2-甲氧基乙酯
• 英文名称: methoxyethyl formate
• 英文别名: 2-Methoxy ethyl formate；2-methoxyethyl formate
• CAS: 628-82-0
• 化学式: C₄H₈O₃
• 分子量: 104.106
• InChiKey: HVSACIINGLQLCS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  7
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  甲酸2-甲氧基乙酯 在 甲酸 、 五氯化磷 作用下， 以 乙二醇甲醚 为溶剂， 生成 dichloromethyl 2-methoxyethyl ether
  参考文献：
  名称：

  Bisphosphonic acids and esters

  摘要：

  本发明涉及迄今为止未知的化合物，其化学式为I，在该式中，R.sub.1是直链或支链、饱和或不饱和的脂肪族或脂环族C.sub.1-C.sub.10烃基，芳基或芳基-C.sub.1-C.sub.4-烷基基团，R.sub.1如有必要，可以是未取代的或取代的，取代基为直链或支链C.sub.1-C.sub.4-烷基，氨基，C.sub.1-C.sub.4-烷氨基，二-(C.sub.1-C.sub.4-烷基)-氨基，羧基，C.sub.1-C.sub.4-烷氧羰基，羟基，C.sub.1-C.sub.4-烷氧基，苯氧基，巯基，C.sub.1-C.sub.4-烷硫基，苯硫基，卤素，三氟甲基；R.sub.2代表氢、C.sub.1-C.sub.8-烷基，芳基-C.sub.1-C.sub.4-烷基或卤素；X为氧或硫，n为0到2的整数；但R.sub.2不能为氢或甲基，如果n=0且R.sub.1为甲基。本发明的化合物在人类和兽医实践中具有重要价值。

  公开号：

  US04732998A1
• 作为产物：
  描述：

  二乙二醇单甲醚 以8%的产率得到
  参考文献：
  名称：

  DARODA R. J.; BLACKBOROW J. R.; WILKINSON G., J. CHEM. SOC. CHEM. COMMUN., 1980, NO 22, 1098-1100

  摘要：

  DOI：

文献信息

• Mild and Highly Selective Formyl Protection of Primary Hydroxyl Groups
  作者：Lidia De Luca、Giampaolo Giacomelli、Andrea Porcheddu

  DOI：10.1021/jo0257492

  日期：2002.7.1

  Efficient conversion of primary alcohols to the corresponding formate esters can be carried out at room temperature in methylene chloride, using 2,4,6-trichloro-1,3,5-triazine and N,N-dimethylformamide in the presence of lithium fluoride. This procedure appears as a valid method for selectively protecting primary hydroxyl groups.

  可以在室温下在二氯甲烷中，在氟化锂的存在下，使用2,4,6-三氯-1,3,5-三嗪和N，N-二甲基甲酰胺在二氯甲烷中将伯醇有效转化为相应的甲酸酯。该程序似乎是选择性保护伯羟基的有效方法。
• Palomaa, Chemisches Zentralblatt, 1913, vol. 84, # II, p. 1956
  作者：Palomaa

  DOI：——

  日期：——
• Synthesis and highly regioselective Diels-Alder reaction of functionalized isoprenes involving a terminal alkoxy group and chemical modification of the resulting adducts
  作者：Tadakatsu Mandai、Kazuhito Osaka、Makoto Kawagishi、Mikio Kawada、Junzo Otera

  DOI：10.1021/jo00193a028

  日期：1984.9
• Mechanisms for the chlorine atom initiated oxidation of dimethoxymethane and 1,2-dimethoxyethane in the presence of NOx
  作者：J. Wenger、E. Porter、E. Collins、J. Treacy、H. Sidebottom

  DOI：10.1016/s0045-6535(98)00509-8

  日期：1999.3

  The chlorine atom initiated gas-phase oxidations of dimethoxymethane and 1,2-dimethoxyethane, have been investigated in the presence of NOx. Methoxymethyl formate and dimethyl carbonate were identified as the oxidation products of dimethoxymethane with molar yields of 0.72 +/- 0.05 and 0.26 +/- 0.02 respectively. The oxidation products of 1,2-dimethoxyethane were methyl formate (1.51 +/- 0.16) and methoxyethyl formate (0.11 +/- 0.01). The results of these studies are used to elucidate simplified gas-phase atmospheric degradation schemes for the diethers and also provide valuable information on the atmospheric fate of the alkoxy radicals produced in these and similar reactions.
• Kinetic Studies on the Reactions of Hydroxyl Radicals with a Series of Alkoxy Esters
  作者：S. M. O'Donnel、H. W. Sidebottom、J. C. Wenger、A. Mellouki、G. Le Bras

  DOI：10.1021/jp048782w

  日期：2004.9.1

  Rate coefficients for the gas-phase reactions of hydroxyl radicals with a series of alkoxy esters of structure RC(O)O(CH2)(n)OR', where R = H, CH3, R' = CH3, C2H5, and n = 1-2, have been determined with use of relative and absolute rate methods. Relative rate measurements were performed in a Teflon reaction chamber at 298 +/- 2 K and atmospheric pressure. Absolute rate measurements were made with pulsed laser photolysislaser induced fluorescence over the temperature range 263-372 K at pressures of similar to100 Torr. The kinetic data are used to derive Arrhenius expressions for the reactions and tropospheric lifetimes for the alkoxy esters. The reactivity of the alkoxy esters is discussed in light of the current understanding of the atmospheric chemistry of oxygenated organic compounds.