N-Isopropylcrotonamid | 67617-61-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-Isopropylcrotonamid
• 英文别名: N-isopropylcrotoneamide；N-(Propan-2-yl)but-2-enamide；N-propan-2-ylbut-2-enamide
• CAS: 67617-61-2
• 化学式: C₇H₁₃NO
• 分子量: 127.186
• InChiKey: PMYOYDPRILKMKB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (E)-But-2-enoic acid cyclohex-2-enyl-isopropyl-amide 生成 N-Isopropylcrotonamid
  参考文献：
  名称：

  Schmitz,E. et al., Journal fur praktische Chemie (Leipzig 1954), 1979, vol. 321, p. 387 - 394

  摘要：

  DOI：

文献信息

• METHOD FOR SYNTHESIZING SAPROPTERIN DIHYDROCHLORIDE
  申请人：ASYMCHEM LABORATORIES (TIANJIN)CO., LTD.

  公开号：US20150119573A1

  公开（公告）日：2015-04-30

  Disclosed is a method for synthesizing sapropterin dihydrochloride. The present disclosure reduces a synthesis route of the sapropterin dihydrochloride, and resolves a racemate intermediate or an intermediate having a low antimer isomerism value by using a chiral resolving reagent, thereby obtaining an intermediate having a high antimer isomerism value. Raw materials are cheap and readily available, and the cost is significantly reduced, hence providing an effective scheme for mass industrial production of the sapropterin dihydrochloride.

  公开了一种合成盐酸沙普曲酮的方法。本公开通过使用手性分离试剂减少了盐酸沙普曲酮的合成路线，并解决了一个具有低对映异构体值的混合物中间体或中间体，从而获得一个具有高对映异构体值的中间体。原材料价格便宜且易得，成本显著降低，因此为盐酸沙普曲酮的大规模工业生产提供了有效方案。
• Mechanistic Insights into Polar Monomer Insertion Polymerization from Acrylamides
  作者：Tobias Friedberger、Philipp Wucher、Stefan Mecking

  DOI：10.1021/ja207110u

  日期：2012.1.18

  fragment occur to afford a ca. 4:1 mixture of chelates [(P^O)Pdκ(2)-C,O-C(CH(2)CH(3))C(O)NMe(2)}] (3) and [(P^O)Pdκ(2)-C,O-CH(2)C(CH(3))C(O)NMe(2)}] (4). The four-membered chelate of 3 is opened by coordination of 2,6-lutidine (3 + 2,6-lutidine ⇌ 3-LUT) with ΔH° = -41.8(10.5) kJ and ΔS° = -115(37) J mol(-1) K(-1).

  N-异丙基丙烯酰胺 (NIPAM)、N,N-二甲基丙烯酰胺 (DMAA) 和 2-乙酰氨基乙基丙烯酸酯 (AcAMEA) 使用 [(P^O)PdMe(DMSO)] (1-DMSO; P^O) 与乙烯共聚= κ(2)-P,O-Ar(2)PC(6)H(4)SO(2)O，Ar = 2-MeOC(6)H(4)) 作为催化剂前体。使用不可聚合的极性添加剂进行的抑制研究表明，游离酰胺的可逆 κ-O 配位显着延缓了聚合反应。聚合的延迟增加的顺序是乙酸乙酯≪甲乙砜<乙腈
• POLYMERIZATION CATALYST, NOVEL TRANSITION METAL COMPOUND, AND POLYMERIZATION METHOD AND COPOLYMER USING THEM
  申请人：Mitsui Chemicals, Inc.

  公开号：EP1092729A1

  公开（公告）日：2001-04-18

  This invention relates to polymerization catalysts for unsaturated monomers which are represented by the following general formula [1]:         MR1kR2mR3nQh     [1] wherein R1 is selected from ligands having at least one nitrogen, sulfur, phosphorus or oxygen atom; R2 is selected from ligands comprising cyclic hydrocarbons having π-electrons, and R1 and R2 may be crosslinked with each other; R3 is selected from ligands comprising a hydrogen atom, alkyl groups, aryl groups, silicon-containing alkyl groups and silicon-containing aryl groups; M is a metal selected from the metals of group III of the periodic table; Q is selected from halogen atoms and electron-donating ligands, where Q may be the same or different if h is more than one; k is an integer of 1 to 4; and m, n and h are each 0 or an integer of 1 to 4.

  本发明涉及不饱和单体的聚合催化剂，其通式如下[1]： MR1kR2mR3nQh [1]. 其中R1选自至少有一个氮、硫、磷或氧原子的配体；R2选自由有π电子的环烃组成的配体，R1和R2可相互交联；R3选自由氢原子、烷基、芳基、含硅烷基和含硅芳基组成的配体；M 是选自元素周期表第 III 族金属的金属；Q 是选自卤素原子和电子捐赠配体的配体，其中如果 h 多于一个，Q 可以相同或不同；k 是 1 至 4 的整数；m、n 和 h 各为 0 或 1 至 4 的整数。
• THERMOSENSITIVE POLYMERS FOR THERAPEUTIC USE AND METHODS OF PREPARATION
  申请人：Agency for Science, Technology and Research

  公开号：EP1648948A1

  公开（公告）日：2006-04-26
• US6703459B1
  申请人：——

  公开号：US6703459B1

  公开（公告）日：2004-03-09