(2R)-N-(1-benzylpiperidin-4-yl)-3-cyclohexylmethylthio-2-(((4R)-thiazolidin-4-ylmethyl)amino)propanamide | 253307-02-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2R)-N-(1-benzylpiperidin-4-yl)-3-cyclohexylmethylthio-2-(((4R)-thiazolidin-4-ylmethyl)amino)propanamide
• 英文别名: (2R)-N-(1-benzylpiperidin-4-yl)-3-(cyclohexylmethylsulfanyl)-2-[[(4R)-1,3-thiazolidin-4-yl]methylamino]propanamide
• CAS: 253307-02-7
• 化学式: C₂₆H₄₂N₄OS₂
• 分子量: 490.778
• InChiKey: ZFOAIWMLIZXYCO-RPBOFIJWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  33
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  107
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Amino acid derivatives and pharmaceutical composition comprising, as active ingredients, them
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：US20030232806A1

  公开（公告）日：2003-12-18

  The present invention relates to the compounds of the formula (I) and salts thereof (all the symbols are the same meanings as described in the specification). 1 The compounds of the formula (I) possess inhibitory activity of N-type calcium channel, so they are useful as drug for prevention and/or treatment of cerebral infarct, transient ischemic attack, encephalomyelopathy after cardiac operation, spinal angiopathy, hypertension with stress, neurosis, epilepsy, asthma and pollakiuria etc. or agent for the treatment of pain

  本发明涉及化合物(I)及其盐（其中所有符号的含义与说明书中描述的相同）。化合物(I)具有N型钙通道的抑制活性，因此它们可用作预防和/或治疗脑梗死、短暂性脑缺血发作、心脏手术后脑脊髓病、脊髓血管病、应激性高血压、神经症、癫痫、哮喘和尿频等疾病的药物，或用作治疗疼痛的药剂。
• AMINO ACID DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP1090912A1

  公开（公告）日：2001-04-11

  Compounds represented by general formula (I) and salts thereof, wherein each symbol is as defined in the specification. Because of inhibiting the N type calcium channel, the compounds of general formula (I) are useful as preventives and/or remedies for brain infarction, transient ischemic attack, cerebrospinal failure following heart operation, spinal vascular failure, stress hypertension, neurosis, epilepsy, asthma, frequent urination, etc. or analgesics.

  通式(I)代表的化合物及其盐类，其中各符号如说明书中所定义。由于能抑制 N 型钙通道，通式（I）化合物可作为脑梗塞、短暂性脑缺血发作、心脏手术后脑脊髓衰竭、脊髓血管衰竭、应激性高血压、神经官能症、癫痫、哮喘、尿频等疾病的预防和/或治疗药物或镇痛剂。
• US6605608B1
  申请人：——

  公开号：US6605608B1

  公开（公告）日：2003-08-12
• US7351721B2
  申请人：——

  公开号：US7351721B2

  公开（公告）日：2008-04-01