2-{2,2-difluoro-2-[3-(4,4,4-trifluorobutoxy)phenyl]ethylamino}-1-(pyrrolidin-1-yl)ethanone | 1417441-72-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-{2,2-difluoro-2-[3-(4,4,4-trifluorobutoxy)phenyl]ethylamino}-1-(pyrrolidin-1-yl)ethanone
• 英文别名: 2-[[2,2-Difluoro-2-[3-(4,4,4-trifluorobutoxy)phenyl]ethyl]amino]-1-pyrrolidin-1-ylethanone；2-[[2,2-difluoro-2-[3-(4,4,4-trifluorobutoxy)phenyl]ethyl]amino]-1-pyrrolidin-1-ylethanone
• CAS: 1417441-72-5
• 化学式: C₁₈H₂₃F₅N₂O₂
• 分子量: 394.385
• InChiKey: SXYKINBAZCLVRK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  27
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• FLUORINATED ARYLALKYLAMINOCARBOXAMIDE DERIVATIVES
  申请人：Pevarello Paolo

  公开号：US20140088074A1

  公开（公告）日：2014-03-27

  Fluorinated arylalkylaminocarboxamide derivatives of formula (I) are described wherein W, J, n, R 1 , R 2 , R 3 , R 4 , R 5 and R 6 have the meanings as defined in the specification and pharmaceutically salts thereof, pharmaceutical compositions containing them as active ingredients and their use as sodium and/or calcium channel modulators useful in preventing, alleviating and curing a wide range of pathologies, including neurological, psychiatric, cardiovascular, inflammatory, ophthalmic, urological, and gastrointestinal diseases, where the above mechanisms have been described as playing a pathological role.

  描述了公式(I)的氟化芳基烷基氨基羧酰胺衍生物，其中W、J、n、R1、R2、R3、R4、R5和R6的含义如规范中所定义，并且其药用盐、含有它们作为活性成分的药物组合物以及它们作为钠和/或钙通道调节剂的用途，用于预防、缓解和治愈包括神经、精神、心血管、炎症、眼科、泌尿和消化系统疾病在内的广泛病症，其中上述机制已被描述为发挥病理作用。
• US9447029B2
  申请人：——

  公开号：US9447029B2

  公开（公告）日：2016-09-20
• [EN] FLUORINATED ARYLALKYLAMINOCARBOXAMIDE DERIVATIVES<br/>[FR] DÉRIVÉS D'ARYLALKYLAMINOCARBOXAMIDES FLUORÉS
  申请人：NEWRON PHARM SPA

  公开号：WO2013000651A1

  公开（公告）日：2013-01-03

  Fluorinated arylalkylaminocarboxamide derivatives of formula (I) are described wherein W, J, n, R1, R2, R2', R3, R4, R5 and R6 have the meanings as defined in the specification and pharmaceutically salts thereof, pharmaceutical compositions containing them as active ingredients and their use as sodium and/or calcium channel modulators useful in preventing, alleviating and curing a wide range of pathologies, including neurological, psychiatric, cardiovascular, inflammatory, ophtalmic, urolological, and gastrointestinal diseases, where the above mechanisms have been described as playing a pathological role.