癸二酸单钠 | 19455-73-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 癸二酸单钠
• 中文别名: 癸二酸单钠;癸二酸氢钠
• 英文名称: monosodium sebacate
• 英文别名: Sodium hydrogen sebacate；sodium;10-hydroxy-10-oxodecanoate
• CAS: 19455-73-3
• 化学式: C₁₀H₁₇O₄*Na
• 分子量: 224.232
• InChiKey: GAQDIDQMKWSQAH-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -2.05
• 重原子数：
  15
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  77.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  14-iodo-N-(trifluoroacetyl)daunorubicin 、 癸二酸单钠 以 水 、 丙酮 为溶剂， 反应 14.0h， 以63%的产率得到N-(trifluoroacetyl)adriamycin 14-O-hemisebacate
  参考文献：
  名称：

  Adriamycin analogs. Rationale, synthesis, and preliminary antitumor evaluation of highly active DNA-nonbinding N-(trifluoroacetyl)adriamycin 14-O-hemiester derivatives

  摘要：

  N-(Trifluoroacetyl)adriamycin 14-valerate (AD 32), a novel DNA nonbinding analogue of adriamycin with superior experimental antitumor activity, has undergone extensive clinical trial, with documentation of antitumor activity and low toxicity in human subjects. However, poor water solubility necessitates that the drug be administered to patients by continuous intravenous infusion at high dilution in a surfactant-containing formulation, with steroid prophylaxis to protect against a chest pain syndrome associated with the vehicle. On the basis of pharmacologic considerations, the title compounds have been prepared as second-generation analogues of N-(trifluoroacetyl)adriamycin 14-valerate with improved aqueous solubility; use is made of the available carboxylic acid function to solubilize the products in dilute aqueous alkaline medium. Target compounds were made by treating N-(trifluoroacetyl)-14-halodaunorubicin (bromo or iodo) with monosodium salts of dibasic acids (malonic, succinic, glutaric, adipic, pimelic, azelaic, sebacic) in aqueous acetone. All of the products showed significant in vivo antitumor activity against the murine P388 leukemia (ip tumor, ip treatment once daily on days 1, 2, 3, and 4); most compounds were superior to the +181% increase in life span afforded by adriamycin (optimal dose 3.0 mg/kg per day), one of two drugs used as positive controls for the assays. Several of the test compounds showed highly curative activity in this system, similar to N-(trifluoroacetyl)adriamycin 14-valerate, the other positive control agent. The hemiadipate product exhibited the most desirable properties of high antitumor efficacy (86% cure rate all P388 tumor-bearing animals through four levels of a 40-70 mg/kg dose-response range), aqueous solubility (60 mg/mL in pH 7.4 phosphate buffer), and solution stability (no decomposition at 4 degrees C, 0.5% hydrolysis at 27 degrees C, over 24 h at pH 7.4).

  DOI：

  10.1021/jm00147a017

文献信息

• Lubricant composition and bearing using same
  申请人：NTN CORPORATION

  公开号：EP1496103A2

  公开（公告）日：2005-01-12

  A lubricant composition capable of effectively preventing a rolling surface of a bearing from flaking owing to hydrogen embrittlement. The bearing is lubricated with the lubricant composition. The lubricant composition is lubricating oil or grease. The lubricant composition contains a molybdate. The lubricant composition also contains an organic acid salt. At least one molybdate is selected from sodium molybdate, potassium molybdate, and lithium molybdate. The organic acid salt is a sodium salt of an organic acid having one to 20 carbon atoms. 0.01 to 5 wt% of the molybdate is added to the entirety of the lubricant composition. 5 wt% to 70 wt% of the organic acid salt is added to the addition amount of the molybdate. The lubricant composition has a function of forming a film containing a molybdenum compound in addition to an iron oxide film on a worn surface of the bearing or on a fresh surface of an iron-based metal generated by wear. The bearing is used as a rolling bearing for use in electric parts and auxiliary machines of a vehicle. The bearing is also used as a bearing, for a motor, in which the lubricant composition is sealed.

  一种能有效防止轴承滚动表面因氢脆而剥落的润滑剂组合物。轴承使用该润滑剂组合物进行润滑。润滑剂组合物是润滑油或润滑脂。润滑剂组合物含有钼酸盐。润滑剂组合物还含有一种有机酸盐。至少一种钼酸盐选自钼酸钠、钼酸钾和钼酸锂。有机酸盐是具有 1 至 20 个碳原子的有机酸的钠盐。在整个润滑油组合物中加入 0.01 至 5 wt%的钼酸盐。在钼酸盐的添加量中加入 5 重量％至 70 重量％的有机酸盐。润滑剂组合物的作用是在轴承磨损表面或磨损产生的铁基金属新表面上形成一层除氧化铁膜外还含有钼化合物的膜。该轴承用作滚动轴承，用于车辆的电气部件和辅助机械。该轴承还可用作电机轴承，其中的润滑剂组合物是密封的。
• GREASE COMPOSITION AND GREASE-SEALED ROLLER BEARING
  申请人：NTN Corporation

  公开号：EP3336161A1

  公开（公告）日：2018-06-20

  Provided is a grease composition which can be used as a lubricant for roller bearings, exhibits excellent high temperature durability and rust preventive property, and can prevent premature flaking on the rolling surface due to hydrogen embrittlement. A roller bearing 1 is obtained by sealing a grease composition 7 in the periphery of a rolling element 4, this grease composition 7 is composed of a base oil excluding an ester-based synthetic oil, a thickener, and an additive, the additive contains (a) an alkanolamine and (b) 2,2,4-trimethyl-1, 2-dihydroquinoline or a polymer thereof but does not contain an organic sulfonate, and (a) and (b) are contained at from 0.1 to 10 parts by weight with respect to 100 parts by weight of a total amount of the base oil and the thickener, respectively.

  本发明提供了一种润滑脂组合物，可用作滚子轴承的润滑剂，具有优异的高温耐久性和防锈性，并能防止滚动表面因氢脆而过早剥落。滚柱轴承 1 是通过在滚动体 4 的外围密封润滑脂组合物 7 而获得的，该润滑脂组合物 7 由基础油（不包括酯基合成油）、稠化剂和添加剂组成，添加剂包含 (a) 烷醇胺和 (b) 2，2，4-三甲基-1，2-二氢喹啉或其聚合物，但不包含有机磺酸盐，且 (a) 和 (b) 的含量为 0.相对于 100 重量份的基础油和增稠剂总量，(a)和(b)的含量分别为 0.1 至 10 重量份。
• Grease composition and grease-sealed roller bearing
  申请人：NTN CORPORATION

  公开号：US10597598B2

  公开（公告）日：2020-03-24

  Provided is a grease composition which can be used as a lubricant for roller bearings, exhibits excellent high temperature durability and rust preventive property, and can prevent premature flaking on the rolling surface due to hydrogen embrittlement. A roller bearing 1 is obtained by sealing a grease composition 7 in the periphery of a rolling element 4, this grease composition 7 is composed of a base oil excluding an ester-based synthetic oil, a thickener, and an additive, the additive contains (a) an alkanolamine and (b) 2,2,4-trimethyl-1,2-dihydroquinoline or a polymer thereof but does not contain an organic sulfonate, and (a) and (b) are contained at from 0.1 to 10 parts by weight with respect to 100 parts by weight of a total amount of the base oil and the thickener, respectively.

  本发明提供了一种润滑脂组合物，可用作滚子轴承的润滑剂，具有优异的高温耐久性和防锈性，并能防止滚动表面因氢脆而过早剥落。滚柱轴承 1 是通过在滚动体 4 的外围密封润滑脂组合物 7 而获得的，该润滑脂组合物 7 由基础油（不包括酯基合成油）、稠化剂和添加剂组成，添加剂包含 (a) 烷醇胺和 (b) 2，2，4-三甲基-1，2-二氢喹啉或其聚合物，但不包含有机磺酸盐，且 (a) 和 (b) 的含量为 0.相对于 100 重量份的基础油和增稠剂总量，(a)和(b)的含量分别为 0.1 至 10 重量份。
• LUBRICANT COMPOSITION AND BEARING USING SAME
  申请人：Kohara Mika

  公开号：US20120277132A1

  公开（公告）日：2012-11-01

  A lubricant composition capable of effectively preventing a rolling surface of a bearing from flaking owing to hydrogen embrittlement. The bearing is lubricated with the lubricant composition. The lubricant composition is lubricating oil or grease. The lubricant composition contains a molybdate. The lubricant composition also contains an organic acid salt. At least one molybdate is selected from sodium molybdate, potassium molybdate, and lithium molybdate. The organic acid salt is a sodium salt of an organic acid having one to 20 carbon atoms. 0.01 to 5 wt % of the molybdate is added to the entirety of the lubricant composition. 5 wt % to 70 wt % of the organic acid salt is added to the addition amount of the molybdate. The lubricant composition forms a film containing a molybdenum compound in addition to an iron oxide film on a worn surface of the bearing.
• ROLLING BEARING
  申请人：MINEBEA MITSUMI INC.

  公开号：US20170343045A1

  公开（公告）日：2017-11-30

  A rolling bearing is filled with a grease composition that contains a fluorine-based grease including a fluorine-based base oil and a fluorine-based thickener, a non-fluorine-based grease including a non-fluorine-based base oil and a non-fluorine-based thickener, and an additive serving as a dispersant. The non-fluorine-based thickener includes at least one of aliphatic-aromatic urea, alicyclic-aliphatic urea and aliphatic urea. The dispersant includes at least one of polycarboxylic acid metal salt, fluorine-containing group/lipophilic group-containing oligomer, fluorinated ether diamide, and organic acid metal salt.