2-[5-[(3-phenoxyphenyl)methoxy]-1H-indol-3-yl]ethanamine;hydrochloride | 339280-38-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[5-[(3-phenoxyphenyl)methoxy]-1H-indol-3-yl]ethanamine;hydrochloride
• CAS: 339280-38-5
• 化学式: C₂₃H₂₂N₂O₂*ClH
• 分子量: 394.901
• InChiKey: QIXHONYXMGWOAK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.46
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  60.3
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-[5-[(3-phenoxyphenyl)methoxy]-1H-indol-3-yl]ethanamine;hydrochloride 在 caesium carbonate 、 sodium hydroxide 作用下， 以 甲醇 、 水 、 丙酮 为溶剂， 生成 3-[2-[5-[(3-phenoxyphenyl)methoxy]-1H-indol-3-yl]ethylamino]propanoic acid
  参考文献：
  名称：

  Optimization of 5-hydroxytryptamines as dual function inhibitors targeting phospholipase A2 and leukotriene A4 hydrolase

  摘要：

  Dual function inhibitors targeting phospholipase A(2) (PLA(2)) and leukotriene A(4) hydrolase (LTA(4)H) may balance the arachidonic acid (AA) metabolic network and be used as new anti-inflammatory drugs. In previous study, we discovered multi-target drugs towards the AA metabolic network, among which a dual-target inhibitor (JMC08-4) for human nonpancreatic secretory phospholipase A(2) (hnps-PLA(2)) and human leukotriene A(4) hydrolase (LTA(4)H-h) was found. Based on the structure of compound JMC08-4, new dual-target inhibitors were designed assisted by molecular docking. In this report, a series of 5-hydroxytryptamine compounds were synthesized; and most of these title compounds showed more potent inhibitory activity than compound JMC08-4 in the in vitro bioassay against these two enzymes. The best one inhibited hnps-PLA(2) and LTA(4)H-h with IC50 values of 9.2 +/- 0.5 mu M and 2.4 +/- 1.4 mu M, respectively. (C) 2012 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.10.057
• 作为产物：
  描述：

  5-羟基色胺盐酸盐 在 盐酸 、 碳酸氢钠 、 caesium carbonate 、 sodium chloride 作用下， 以 氯仿 、 水 、 乙酸乙酯 、 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 生成 2-[5-[(3-phenoxyphenyl)methoxy]-1H-indol-3-yl]ethanamine;hydrochloride
  参考文献：
  名称：

  Optimization of 5-hydroxytryptamines as dual function inhibitors targeting phospholipase A2 and leukotriene A4 hydrolase

  摘要：

  Dual function inhibitors targeting phospholipase A(2) (PLA(2)) and leukotriene A(4) hydrolase (LTA(4)H) may balance the arachidonic acid (AA) metabolic network and be used as new anti-inflammatory drugs. In previous study, we discovered multi-target drugs towards the AA metabolic network, among which a dual-target inhibitor (JMC08-4) for human nonpancreatic secretory phospholipase A(2) (hnps-PLA(2)) and human leukotriene A(4) hydrolase (LTA(4)H-h) was found. Based on the structure of compound JMC08-4, new dual-target inhibitors were designed assisted by molecular docking. In this report, a series of 5-hydroxytryptamine compounds were synthesized; and most of these title compounds showed more potent inhibitory activity than compound JMC08-4 in the in vitro bioassay against these two enzymes. The best one inhibited hnps-PLA(2) and LTA(4)H-h with IC50 values of 9.2 +/- 0.5 mu M and 2.4 +/- 1.4 mu M, respectively. (C) 2012 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.10.057

文献信息

• NOVEL ANTI-INFECTIVES
  申请人：——

  公开号：US20010007877A1

  公开（公告）日：2001-07-12

  Novel anti-infectives and methods of using them are provided.

  提供了新型抗感染药物及其使用方法。
• [EN] NOVEL ANTI-INFECTIVES<br/>[FR] ANTI-INFECTIEUX
  申请人：SMITHKLINE BEECHAM CORP

  公开号：WO2001034146A1

  公开（公告）日：2001-05-17

  Novel anti-infectives and methods of using them are provided.

  提供了新型抗感染剂及其使用方法。
• Novel anti-infectives
  申请人：——

  公开号：US20020004198A1

  公开（公告）日：2002-01-10

  Novel anti-infectives and methods of using them are provided. Also disclosed is a method to identify a compound that inhibits the interaction of a herpesvirus major capsid protein and a herpesvirus scaffolding protein or protease.

  本发明提供了新型抗感染剂及其使用方法。同时还揭示了一种方法，用于识别抑制疱疹病毒主要外壳蛋白和疱疹病毒支架蛋白或蛋白酶相互作用的化合物。
• Optimization of 5-hydroxytryptamines as dual function inhibitors targeting phospholipase A2 and leukotriene A4 hydrolase
  作者：Hu Meng、Ying Liu、Yujing Zhai、Luhua Lai

  DOI：10.1016/j.ejmech.2012.10.057

  日期：2013.1

  Dual function inhibitors targeting phospholipase A(2) (PLA(2)) and leukotriene A(4) hydrolase (LTA(4)H) may balance the arachidonic acid (AA) metabolic network and be used as new anti-inflammatory drugs. In previous study, we discovered multi-target drugs towards the AA metabolic network, among which a dual-target inhibitor (JMC08-4) for human nonpancreatic secretory phospholipase A(2) (hnps-PLA(2)) and human leukotriene A(4) hydrolase (LTA(4)H-h) was found. Based on the structure of compound JMC08-4, new dual-target inhibitors were designed assisted by molecular docking. In this report, a series of 5-hydroxytryptamine compounds were synthesized; and most of these title compounds showed more potent inhibitory activity than compound JMC08-4 in the in vitro bioassay against these two enzymes. The best one inhibited hnps-PLA(2) and LTA(4)H-h with IC50 values of 9.2 +/- 0.5 mu M and 2.4 +/- 1.4 mu M, respectively. (C) 2012 Elsevier Masson SAS. All rights reserved.