Butandiol-1,4-bis-(N-vinylcarbamat) | 6420-58-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Butandiol-1,4-bis-(N-vinylcarbamat)
• 英文别名: 4-(ethenylcarbamoyloxy)butyl N-ethenylcarbamate
• CAS: 6420-58-2
• 化学式: C₁₀H₁₆N₂O₄
• 分子量: 228.248
• InChiKey: SXAHULNRECHJIA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  16
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  76.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1,4-丁二醇 、 异氰酸乙烯酯 生成 Butandiol-1,4-bis-(N-vinylcarbamat)
  参考文献：
  名称：

  Über die Synthese einiger N-Vinyl-verbindungen

  摘要：

  DOI：

  10.1007/bf01153885

文献信息

• Ophthalmic devices
  申请人：Bausch & Lomb Incorporated

  公开号：US10668676B2

  公开（公告）日：2020-06-02

  An ophthalmic device is disclosed that is a polymerization product of a monomeric mixture comprising: (a) a major amount of one or more non-silicone-containing hydrophilic monomers; (b) a crosslinking agent mixture comprising (i) one or more first crosslinking agents containing at least two ethylenically unsaturated reactive end groups, wherein the at least two ethylenically unsaturated reactive end groups are (meth)acrylate-containing reactive end groups and (ii) one or more second crosslinking agents containing at least two ethylenically unsaturated reactive end groups wherein at least one of the ethylenically unsaturated reactive end groups is a non-(meth)acrylate reactive end group, and (c) one or more hydrophilic polymers or copolymers comprising one or more hydrophilic units and a thio carbonyl thio fragment of a reversible addition fragmentation chain transfer (“RAFT”) agent wherein the ophthalmic device has an equilibrium water content of at least about 45 weight percent.

  本发明公开了一种眼科设备，它是一种单体混合物的聚合产物，该单体混合物包括(a) 一种或多种主要量的非含硅亲水单体；(b) 交联剂混合物，包括(i)一种或多种含有至少两个乙烯不饱和反应性末端基团的第一交联剂，其中至少两个乙烯不饱和反应性末端基团为含(甲基)丙烯酸酯反应性末端基团；(ii)一种或多种含有至少两个乙烯不饱和反应性末端基团的第二交联剂，其中至少一个乙烯不饱和反应性末端基团为非(甲基)丙烯酸酯反应性末端基团、(c) 一种或多种亲水聚合物或共聚物，包含一种或多种亲水单元和可逆加成片段链转移 （"RAFT"）剂的硫代羰基硫代片段，其中眼科装置的平衡水含量至少为约 45 重量百分 比。
• Water extractable ophthalmic devices
  申请人：Bausch & Lomb Incorporated

  公开号：US11022722B2

  公开（公告）日：2021-06-01

  A water extractable ophthalmic device is disclosed which is a polymerization product of a monomeric mixture comprising: (a) one or more cyclic lactams; (b) one or more organosilicon-containing block copolymers; (c) one or more bulky siloxane monomers; and (d) a crosslinking agent mixture comprising (i) one or more first crosslinking agents containing at least two ethylenically unsaturated reactive end groups, wherein the at least two ethylenically unsaturated reactive end groups are (meth)acrylate-containing reactive end groups and (ii) one or more second crosslinking agents containing at least two ethylenically unsaturated reactive end groups wherein at least one of the ethylenically unsaturated reactive end groups is a non-(meth)acrylate reactive end group. The water extractable ophthalmic device has an equilibrium water content of at least about 50 wt. %, a contact angle of less than about 50°, and an oxygen permeability of at least about 60 Barrers.

  本发明公开了一种水萃取眼科装置，它是一种单体混合物的聚合产物，该单体混合物包括(a) 一种或多种环内酰胺； (b) 一种或多种含有机硅的嵌段共聚物； (c) 一种或多种大体积硅氧烷单体；(d) 交联剂混合物，包括(i)一种或多种含有至少两个乙烯不饱和反应性末端基团的第一交联剂，其中至少两个乙烯不饱和反应性末端基团为含(甲基)丙烯酸酯反应性末端基团；(ii)一种或多种含有至少两个乙烯不饱和反应性末端基团的第二交联剂，其中至少一个乙烯不饱和反应性末端基团为非(甲基)丙烯酸酯反应性末端基团。水萃取眼科装置的平衡水含量至少约为 50 wt.%，接触角小于约 50°，氧气渗透性至少约为 60 Barrers。
• WATER EXTRACTABLE OPHTHALMIC DEVICES
  申请人：Bausch & Lomb Incorporated

  公开号：EP3794388A1

  公开（公告）日：2021-03-24
• OPHTHALMIC DEVICES
  申请人：Bausch & Lomb Incorporated

  公开号：US20200047437A1

  公开（公告）日：2020-02-13

  An ophthalmic device is disclosed that is a polymerization product of a monomeric mixture comprising: (a) a major amount of one or more non-silicone-containing hydrophilic monomers; (b) a crosslinking agent mixture comprising (i) one or more first crosslinking agents containing at least two ethylenically unsaturated reactive end groups, wherein the at least two ethylenically unsaturated reactive end groups are (meth)acrylate-containing reactive end groups and (ii) one or more second crosslinking agents containing at least two ethylenically unsaturated reactive end groups wherein at least one of the ethylenically unsaturated reactive end groups is a non-(meth)acrylate reactive end group, and (c) one or more hydrophilic polymers or copolymers comprising one or more hydrophilic units and a thio carbonyl thio fragment of a reversible addition fragmentation chain transfer (“RAFT”) agent wherein the ophthalmic device has an equilibrium water content of at least about 45 weight percent.
• Über die Synthese einiger N-Vinyl-verbindungen
  作者：Rolf C. Schulz、Heinrich Hartmann

  DOI：10.1007/bf01153885

  日期：1961.3