10-(2,5-bis{[2-(Trimethylsilyl)ethoxy]methoxy}phenoxy)-1-vinyl-11-dodecenyl 2-methyl-5-{[2-(trimethylsilyl)ethoxy]methoxy}phenyl ether | 1068572-34-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 10-(2,5-bis{[2-(Trimethylsilyl)ethoxy]methoxy}phenoxy)-1-vinyl-11-dodecenyl 2-methyl-5-{[2-(trimethylsilyl)ethoxy]methoxy}phenyl ether
• CAS: 1068572-34-8
• 化学式: C₄₅H₇₈O₈Si₃
• 分子量: 831.366
• InChiKey: LGYPTEUZEQPQPH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.76
• 重原子数：
  56.0
• 可旋转键数：
  33.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  73.84
• 氢给体数：
  0.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  10-(2,5-bis{[2-(Trimethylsilyl)ethoxy]methoxy}phenoxy)-1-vinyl-11-dodecenyl 2-methyl-5-{[2-(trimethylsilyl)ethoxy]methoxy}phenyl ether 以 间二甲苯 为溶剂， 反应 2.0h， 以56%的产率得到3-((2-(trimethylsilyl)ethoxy)methoxy)-2-(14-(3,6-bis((2-trimethylsilyl)ethoxymethoxy)-2-hydroxyphenyl)tetradeca-2,12-dienyl)-6-methylphenol
  参考文献：
  名称：

  Synthesis of the Reported Structure of the Bisbenzoquinone Lanciaquinone, Isolated from Maesa lanceolata

  摘要：

  Lanciaquinone, isolated from Maesa lanceolata, was originally assigned as a bisbenzoquinone with a C-14-chain linking the two quinone rings. A synthesis of the reported structure, in which the key step is a double Claisen rearrangement, suggests that the structure of the natural product needs to be revised.

  DOI：

  10.1021/ol801697g
• 作为产物：
  描述：

  2-methyl-5-{[2-(trimethylsilyl)ethoxy]methoxy}phenol 、 12-(2,5-bis{[2-(trimethylsilyl)ethoxy]methoxy}phenoxy)-1,13-tetradecadien-3-ol 在 三丁基膦 、 偶氮二甲酰二哌啶 作用下， 以 四氢呋喃 为溶剂， 反应 24.5h， 以58%的产率得到10-(2,5-bis{[2-(Trimethylsilyl)ethoxy]methoxy}phenoxy)-1-vinyl-11-dodecenyl 2-methyl-5-{[2-(trimethylsilyl)ethoxy]methoxy}phenyl ether
  参考文献：
  名称：

  Synthesis of the Reported Structure of the Bisbenzoquinone Lanciaquinone, Isolated from Maesa lanceolata

  摘要：

  Lanciaquinone, isolated from Maesa lanceolata, was originally assigned as a bisbenzoquinone with a C-14-chain linking the two quinone rings. A synthesis of the reported structure, in which the key step is a double Claisen rearrangement, suggests that the structure of the natural product needs to be revised.

  DOI：

  10.1021/ol801697g