Ultrasound-promoted synthesis of 2-amino-6-(arylthio)-4-arylpyridine-3,5-dicarbonitriles using ZrOCl2·8H2O/NaNH2 as the catalyst in the ionic liquid [bmim]BF4 at room temperature
摘要:
We herein present an efficient and environmentally benign protocol for the synthesis of 2-amino-6-(arylthio)-4-arylpyridine-3,5-dicarbonitrile derivatives via the three-component condensation of a variety of aldehydes, arylthiols, and malononitrile catalyzed by ZrOCl2 center dot 8H(2)O/NaNH2 (20 mol %) in the ionic liquid [bmim]BF4 under ultrasound irradiation at room temperature. (C) 2011 Elsevier Ltd. All rights reserved.