7-chloro-4-[N-[2-methyl-5-(4-aminophenyl)-3-(pyrrolidin-1-ylmethyl)-1H-pyrrol-1-yl]-amino]quinoline | 1251469-45-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 7-chloro-4-[N-[2-methyl-5-(4-aminophenyl)-3-(pyrrolidin-1-ylmethyl)-1H-pyrrol-1-yl]-amino]quinoline
• 英文别名: N-[5-(4-aminophenyl)-2-methyl-3-(pyrrolidin-1-ylmethyl)pyrrol-1-yl]-7-chloroquinolin-4-amine
• CAS: 1251469-45-0
• 化学式: C₂₅H₂₆ClN₅
• 分子量: 431.968
• InChiKey: JJERQAMHSQATHD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  59.1
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  [5-(4-aminophenyl)-1-[(7-chloroquinolin-4-yl)amino]-2-methyl-1H-pyrrol-3-yl](pyrrolidin-1-yl)methanone 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 以7%的产率得到7-chloro-4-[N-[2-methyl-5-(4-aminophenyl)-3-(pyrrolidin-1-ylmethyl)-1H-pyrrol-1-yl]-amino]quinoline
  参考文献：
  名称：

  Synthesis, antimalarial activity, and cellular toxicity of new arylpyrrolylaminoquinolines

  摘要：

  A set of nine new arylpyrrolyl derivatives of 7-chloro-4-aminoquinoline, characterized by different substituents on the phenyl ring or different distance between the pyrrolic nitrogen and the 4-aminoquinoline, has been synthesized and tested for their activity against D-10 (CQ-S) and W-2 (CQ-R) strains of Plasmodium falciparum. All compounds exhibited activity against the CQ-S strain in the low nM range, comparable to that of chloroquine. Some of them were also highly active against the CQ-R strain and not toxic against normal cells. The antimalarial activity of this new class of compounds seems to be related to the inhibition of heme detoxification process of parasites, as in the case of chloroquine. (c) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.08.001

文献信息

• Synthesis, antimalarial activity, and cellular toxicity of new arylpyrrolylaminoquinolines
  作者：Manolo Casagrande、Nicoletta Basilico、Chiara Rusconi、Donatella Taramelli、Anna Sparatore

  DOI：10.1016/j.bmc.2010.08.001

  日期：2010.9

  A set of nine new arylpyrrolyl derivatives of 7-chloro-4-aminoquinoline, characterized by different substituents on the phenyl ring or different distance between the pyrrolic nitrogen and the 4-aminoquinoline, has been synthesized and tested for their activity against D-10 (CQ-S) and W-2 (CQ-R) strains of Plasmodium falciparum. All compounds exhibited activity against the CQ-S strain in the low nM range, comparable to that of chloroquine. Some of them were also highly active against the CQ-R strain and not toxic against normal cells. The antimalarial activity of this new class of compounds seems to be related to the inhibition of heme detoxification process of parasites, as in the case of chloroquine. (c) 2010 Elsevier Ltd. All rights reserved.