1-allyl 6-pyridin-2-yl hexanedioate | 1257841-73-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 1-allyl 6-pyridin-2-yl hexanedioate
• CAS: 1257841-73-8
• 化学式: C₁₄H₁₇NO₄
• 分子量: 263.293
• InChiKey: QGURIMNXAQPWFY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.28
• 重原子数：
  19.0
• 可旋转键数：
  8.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  65.49
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  1-allyl 6-pyridin-2-yl hexanedioate 、 三氟甲烷磺酸甲酯 以 甲苯 为溶剂， 反应 2.0h， 生成
  参考文献：
  名称：

  Selective deprotection and amidation of 2-pyridyl esters via N-methylation

  摘要：

  The 2-pyridyl residue serves as a protecting group for various carboxylic acids. The protecting group is selectively cleaved under mild conditions via N-methylation of the pyridyl group. During the deprotection process, the various functional groups as well as the other ester moieties remain intact. The N-methylated active esters can be subsequently transformed into amides. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.09.016
• 作为产物：
  描述：

  2-羟基吡啶 、 adipic acid monoallyl ester 在 4-二甲氨基吡啶 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以55%的产率得到1-allyl 6-pyridin-2-yl hexanedioate
  参考文献：
  名称：

  Selective deprotection and amidation of 2-pyridyl esters via N-methylation

  摘要：

  The 2-pyridyl residue serves as a protecting group for various carboxylic acids. The protecting group is selectively cleaved under mild conditions via N-methylation of the pyridyl group. During the deprotection process, the various functional groups as well as the other ester moieties remain intact. The N-methylated active esters can be subsequently transformed into amides. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.09.016