| 1243675-07-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• CAS: 1243675-07-1
• 化学式: C₂₈H₄₅ClN₂O₄Si
• 分子量: 537.215
• InChiKey: FTPCUMZKXOXMJQ-JOCHJYFZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.25
• 重原子数：
  36.0
• 可旋转键数：
  5.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  67.87
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 生成 tert-butyl (1R)-1-(2-aminopropan-2-yl)-5-chloro-6-methylspiro[1,2-dihydroindene-3,4'-piperidine]-1'-carboxylate
  参考文献：
  名称：

  Spiroindane based amides as potent and selective MC4R agonists for the treatment of obesity

  摘要：

  We report a series of potent and selective MC4R agonists based on spiroindane amide privileged structures for potential treatments of obesity. Among the synthetic methods used, Method C allows rapid synthesis of the analogs. The series of compounds can afford high potency on MC4R as well as good rodent pharmacokinetic profiles. Compound 1r (MK-0489) demonstrates MC4R mediated reduction of food intake and body weight in mouse models. Compound 1r is efficacious in 14-day diet-induced obese (DIO) rat models. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.06.062
• 作为产物：
  描述：

  2-(三甲硅基)乙醇 、 生成
  参考文献：
  名称：

  Spiroindane based amides as potent and selective MC4R agonists for the treatment of obesity

  摘要：

  We report a series of potent and selective MC4R agonists based on spiroindane amide privileged structures for potential treatments of obesity. Among the synthetic methods used, Method C allows rapid synthesis of the analogs. The series of compounds can afford high potency on MC4R as well as good rodent pharmacokinetic profiles. Compound 1r (MK-0489) demonstrates MC4R mediated reduction of food intake and body weight in mouse models. Compound 1r is efficacious in 14-day diet-induced obese (DIO) rat models. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.06.062